K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages.
Sang Heon Suh,Kibaek Choe,Seon Pyo Hong,Seung-hwan Jeong,Taija Makinen,Kwang Soon Kim,Kari Alitalo,Charles D Surh,Gou Young Koh,Joo Hye Song +9 more
TL;DR: It is concluded that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.
Journal ArticleDOI
Vascular Endothelial Growth Factor (VEGF) and VEGF-C Show Overlapping Binding Sites in Embryonic Endothelia and Distinct Sites in Differentiated Adult Endothelia
TL;DR: The results show that both VEGF-C and V EGF target embryonic blood vessels, whereas a more selective binding of VEGf-C occurs to its lymphatic vascular receptor in certain adult tissues.
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Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines.
TL;DR: A role for TGF-beta is suggested in the differential regulation of expression of the PDGF genes in human leukemia cell lines after a 1- to 2-h stimulation with an 8 pM concentration of transforming growth factor beta.
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Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema.
Krista Honkonen,Mikko T. Visuri,Tomi V. Tervala,Paavo Halonen,Mari Koivisto,Markku Lähteenvuo,Kari Alitalo,Seppo Ylä-Herttuala,Anne Saaristo +8 more
TL;DR: Lymphangiogenic growth factors improve lymphatic vessel regeneration and lymph node function after lymph node transfer and provide a basis for future clinical trials in lymphedema patients.
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VEGFR3 gene structure, regulatory region, and sequence polymorphisms
Kristiina Iljin,Marika J. Karkkainen,Elizabeth C. Lawrence,Mark A. Kimak,Marko Uutela,Jussi Taipale,Katri Pajusola,Leena Alhonen,Maria Halmekytö,David N. Finegold,Robert E. Ferrell,Kari Alitalo +11 more
TL;DR: The sequence, organization, and variation in the VEGFR3 gene and its regulatory region provide important tools for the molecular genetic analysis of the lymphatic system and its disorders.