K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
More filters
Journal ArticleDOI
Genomic organization of human and mouse genes for vascular endothelial growth factor C.
Dmitri Chilov,Eola Kukk,Suvi Taira,Michael Jeltsch,Jaakko Kaukonen,Aarno Palotie,Vladimir Joukov,Kari Alitalo +7 more
TL;DR: The cloning and characterization of human and mouse genes for VEGF-C, a newly isolated member of the vascular endothelial growth factor/platelet-derived growth factor (VEGF/PDGF) family, shows both similarities and distinct differences in comparison with other members of the V EGF/ PDGF gene family.
Journal Article
Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells.
TL;DR: Results indicate that recombinant endostatin interacts with alpha5beta1 integrin and caveolin-1 at the endothelial cell surface, and the antimigratory effect ofendostatin involves phosphatase-dependent Src activation and impaired cell-matrix interactions.
Journal ArticleDOI
The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man.
Megan E. Baldwin,Bruno Catimel,Edouard C. Nice,Sally Roufail,Nathan E. Hall,Kaye L. Stenvers,Marika J. Karkkainen,Kari Alitalo,Steven A. Stacker,Marc G. Achen +9 more
TL;DR: The unexpected finding that mouse VEGF-D fails to bind mouse V EGFR-2 but binds and cross-links VEGFR-3 is reported as demonstrated by biosensor analysis with immobilized receptor domains and bioassays of VEGfr-2 and VEG FR-3 cross-linking.
Journal Article
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.
Katri Pajusola,Olga Aprelikova,Giuliana Pelicci,Herbert A. Weich,Lena Claesson-Welsh,Kari Alitalo +5 more
TL;DR: It is suggested that the endothelial cell FLT4 receptor tyrosine kinase transmits signals for an as yet unidentified growth factor.
Journal ArticleDOI
Nonvenous Origin of Dermal Lymphatic Vasculature
Ines Martinez-Corral,Maria H. Ulvmar,Lukas Stanczuk,Florence Tatin,Krishnakumar Kizhatil,Simon W. M. John,Kari Alitalo,Sagrario Ortega,Taija Makinen +8 more
TL;DR: It is shown that, contrary to current dogma, a significant part of the dermal lymphatic vasculature forms independently of sprouting from veins.