K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Molecular mechanisms of lymphangiogenesis in health and disease.
Kari Alitalo,Peter Carmeliet +1 more
TL;DR: The recent discovery of the key lymphangiogenic factors VEGF-C and V EGF-D and their receptor VEGFR-3 has allowed novel insights into how the lymphatic vessels and blood vessels coordinately grow and affect human disease.
Journal Article
Vascular Endothelial Growth Factor C Promotes Tumor Lymphangiogenesis and Intralymphatic Tumor Growth
Terhi Karpanen,Mikala Egeblad,Marika J. Karkkainen,Hajime Kubo,Seppo Ylä-Herttuala,Marja Jäättelä,Kari Alitalo +6 more
TL;DR: It is suggested that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGf-C and its receptor.
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Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice
Tanja Veikkola,Lotta Jussila,Taija Makinen,Terhi Karpanen,Michael Jeltsch,Tatiana V. Petrova,Hajime Kubo,Gavin Thurston,Donald M. McDonald,Marc G. Achen,Steven A. Stacker,Kari Alitalo +11 more
TL;DR: It is demonstrated that stimulation of the VEGFR‐3 signal transduction pathway is sufficient to induce specifically lymphangiogenesis in vivo.
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Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome
Yan Zhou,Michael T. McMaster,Kirstin Woo,Mary Janatpour,Jean Perry,Terhi Karpanen,Kari Alitalo,Caroline H. Damsky,Susan J. Fisher +8 more
TL;DR: VEGF family members regulate cytotrophoblast survival and that expression of a subset of family members is dysregulated in severe forms of preeclampsia, which is shown to be key regulators of conventional vasculogenesis and angiogenesis.
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Abnormal lymphatic vessel development in neuropilin 2 mutant mice.
Li Yuan,Delphine Moyon,Luc Pardanaud,Christiane Bréant,Marika J. Karkkainen,Kari Alitalo,Anne Eichmann +6 more
TL;DR: It is reported that neuropilin 2 expression in the vascular system is restricted to veins and lymphatic vessels, and homozygous Nrp2 mutants show absence or severe reduction of small lymphatic Vessels and capillaries during development.