K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
TL;DR: The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system and provide unique insights into the functions of this vascular signalling system.
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Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
Marc G. Achen,Michael Jeltsch,Eola Kukk,Taija Makinen,Angela A. Vitali,Andrew F. Wilks,Kari Alitalo,Steven A. Stacker +7 more
TL;DR: A member of the VEGF family is identified by computer-based homology searching and it is demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other V EGF family members and that corresponds to the mature form of VEGf-C.
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Lymphangiogenesis: Molecular Mechanisms and Future Promise
Tuomas Tammela,Kari Alitalo +1 more
TL;DR: The growth of lymphatic vessels is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity.
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Lymphangiogenesis in development and human disease
Kari Alitalo,Kari Alitalo,Tuomas Tammela,Tuomas Tammela,Tatiana V. Petrova,Tatiana V. Petrova +5 more
TL;DR: The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood in an important role in the pathogenesis of several diseases, including cancer, lymphoedema and various inflammatory conditions.
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Clinical applications of angiogenic growth factors and their inhibitors.
Napoleone Ferrara,Kari Alitalo +1 more
TL;DR: Inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes.