K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
More filters
Journal ArticleDOI
Polarized Vascular Endothelial Growth Factor Secretion by Human Retinal Pigment Epithelium and Localization of Vascular Endothelial Growth Factor Receptors on the Inner Choriocapillaris : Evidence for a Trophic Paracrine Relation
H. G. T. Blaauwgeers,G M Holtkamp,Hugo Rutten,A. N. Witmer,Pieter Koolwijk,Taina A. Partanen,Kari Alitalo,Marielle E. Kroon,Aize Kijlstra,Victor W.M. van Hinsbergh,Reinier O. Schlingemann +10 more
TL;DR: In this paper, the retinal pigment epithelium (RPE) maintains the choriocapillaris (CC) in the normal eye and is involved in the pathogenesis of choroidal neovascularization in age-related macular degeneration.
Journal Article
Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation
TL;DR: It is reported here that functional lymphatic capillaries are absent from the interior of a solid tumor, despite the presence within the tumor of the lymphangiogenic molecule vascular endothelial growth factor and endothelial cells bearing its receptor, VEGF receptor 3.
Journal ArticleDOI
Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
Hsei-Wei Wang,Matthew Trotter,Dimitrios Lagos,Dimitra Bourboulia,Stephen Henderson,Taija Makinen,Stephen Elliman,Adrienne M. Flanagan,Kari Alitalo,Chris Boshoff +9 more
TL;DR: It is shown by gene expression microarrays that neoplastic cells of Kaposi sarcoma are closely related to lymphatic endothelial cells (LECs) and that Kaposi Sarcoma herpesvirus (KSHV) infects both LECs and blood vascular endothelial Cells (BECs) in vitro.
Journal ArticleDOI
Interaction of endostatin with integrins implicated in angiogenesis.
Marko Rehn,Tanja Veikkola,Eola Kukk-Valdre,Hitoshi Nakamura,Maritta Ilmonen,Christian R. Lombardo,Taina Pihlajaniemi,Kari Alitalo,Kristiina Vuori +8 more
TL;DR: It is demonstrated that recombinantly produced human endostatin interacts with alpha(5)- and alpha(v)-integrins on the surface of human endothelial cells, and the interaction is of functional significance in vitro, as it is found that immobilizedendostatin supports endothelial cell survival and migration in an integrin-dependent manner.
Journal ArticleDOI
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
Taija Makinen,Ralf H. Adams,John Bailey,Qiang Lu,Andrew Ziemiecki,Kari Alitalo,Rüdiger Klein,George A. Wilkinson +7 more
TL;DR: These studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions.