K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma.
Mihaela Skobe,Leena Hamberg,Thomas Hawighorst,Michael Schirner,Gerald L. Wolf,Kari Alitalo,Michael Detmar +6 more
TL;DR: The presence of intratumoral lymphatics and enlargement of lymphatic vessels at the tumor periphery in vascular endothelial growth factor (VEGF)-C-overexpressing human melanomas transplanted onto nude mice is demonstrated and VEGF-C is identified as multifunctional factor involved in regulating tumor lymphangiogenesis, angiogenic, and immune response.
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Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
Susanna Purhonen,Jarmo Palm,Derrick J. Rossi,Nina Kaskenpää,Iiro Rajantie,Seppo Ylä-Herttuala,Kari Alitalo,Irving L. Weissman,Petri Salven +8 more
TL;DR: The results show that no BM- derived VEGFR-2+ or other EC precursors contribute to vascular endothelium and that cancer growth does not require BM-derived endothelial progenitors.
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Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation
TL;DR: The lymphatic vascular system is important for immune surveillance, tissue fluid homeostasis and fat absorption, and is involved in many pathological processes, including tumor metastasis and lymphedema, and administration of lymphangiogenic growth factors or their antagonists provides the possibility of targeting lymphatic vessels in human disease.
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
TL;DR: The glymphatic system is discussed as a system that allows CNS perfusion by the cerebrospinal fluid (CSF) and interstitial fluid (ISF), and the recently characterized meningeal lymphatic vessels and their role in drainage of the brain ISF.
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Vascular Endothelial Cell Growth Factor Receptor 3–Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels
Yulong He,Iiro Rajantie,Katri Pajusola,Michael Jeltsch,Tanja Holopainen,Seppo Ylä-Herttuala,Thomas Harding,Karin Jooss,Takashi Takahashi,Kari Alitalo +9 more
TL;DR: It is shown that VEGF-C produced by tumor cells induced extensive lymphatic sprouting towards the tumor cells as well as dilation of the draining lymphatic vessels, suggesting an active role of lymphatic endothelial cells in lymphatic metastasis, which may require the targeting of both tumor lymphangiogenesis and tumor cell invasion.