K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro
Nikolaus Wick,Pipsa Saharinen,Juha Saharinen,Elisabeth Gurnhofer,Carl W. Steiner,Ingrid Raab,Dejan Stokic,Pietro Giovanoli,Sabine Buchsbaum,Aurea Burchard,Stefan Thurner,Kari Alitalo,Dontscho Kerjaschki +12 more
TL;DR: Direct ex vivo analysis of theymphatic endothelial cell transcriptome is helpful for the understanding of the physiology of the lymphatic vascular system and of the pathogenesis of its diseases.
Journal ArticleDOI
Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis
Taina Vuorio,Harri Nurmi,Karen S. Moulton,Jere Kurkipuro,Marius R. Robciuc,Miina Öhman,Suvi E. Heinonen,Haritha Samaranayake,Tommi Heikura,Kari Alitalo,Seppo Ylä-Herttuala +10 more
TL;DR: A novel finding linking impaired lymphatic vessels to lipoprotein metabolism, increased plasma cholesterol levels, and enhanced atherogenesis is shown.
Journal ArticleDOI
Genesis and pathogenesis of lymphatic vessels
TL;DR: An overview of the structure, function, and development of the lymphatics is given, with special emphasis on the recently discovered lymphangiogenic growth factors.
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Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis
Tuomas Tammela,Anne Saaristo,Tanja Holopainen,Seppo Ylä-Herttuala,Leif C. Andersson,Susanna Virolainen,Susanna Virolainen,Ilkka Immonen,Kari Alitalo +8 more
TL;DR: This study investigates whether eradicating tumor-associated lymphatic vessels and the tumor cells they contain using photodynamic therapy (PDT) with a light-activated cytotoxic compound could reduce or eliminate tumor metastasis and demonstrated that this should be feasible.
Journal ArticleDOI
Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet
Sinem Karaman,Maija Hollmén,Marius R. Robciuc,Annamari Alitalo,Harri Nurmi,Bettina Morf,Dorina Buschle,H. Furkan Alkan,Alexandra M. Ochsenbein,Kari Alitalo,Christian Wolfrum,Michael Detmar +11 more
TL;DR: Systemic antibody blockage of VEGFR-3 in db/db mice reduces adipose tissue macrophage infiltration and hepatic lipid accumulation, and improves insulin sensitivity, revealing an unanticipated role of the lymphangiogenic factors VEGF-C and -D in the mediation of metabolic syndrome-associated adipose tissues inflammation.