K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.
Satu Vainikka,Juha Partanen,Paola Bellosta,Coulier F,Birnbaum D,Claudio Basilico,Jaye M,Kari Alitalo +7 more
TL;DR: An FGF binding profile for FGFR‐4 is established with aFGF having the highest affinity, followed by K‐FGF/hst‐1 and bFGF, and FGF‐6 was found to bind to FGFR•4 in ligand competition experiments.
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Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema
Markku Lähteenvuo,Krista Honkonen,Tomi V. Tervala,Tuomas Tammela,Erkki Suominen,Johanna Lähteenvuo,Ivana Kholová,Kari Alitalo,Seppo Ylä-Herttuala,Anne Saaristo +9 more
TL;DR: Results show that growth factor gene therapy coupled with lymph node transfer can be used to repair damaged lymphatic networks in a large animal model and provide a basis for future clinical trials of the treatment of lymphedema.
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Vascular endothelial growth factors VEGF‐B and VEGF‐C
Vladimir Joukov,Arja Kaipainen,Michael Jeltsch,Katri Pajusola,Birgitta Olofsson,Vijay Kumar,Ulf Eriksson,Kari Alitalo +7 more
TL;DR: The role of VEGF in embryogenesis is emphasized by the unprecedented result that the inactivation of even a generated by alternative splicing of mRNA from the V EGF-B gene, spanning about 4 kb of DNA, is emphasized.
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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
Minah Kim,Breanna M. Allen,Emilia A. Korhonen,Maximilian Nitschké,Hee Won Yang,Peter Baluk,Pipsa Saharinen,Kari Alitalo,Christopher Daly,Gavin Thurston,Donald M. McDonald +10 more
TL;DR: Angiopoietin-2 activation of Tie2 supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 in inflammation leads to ANG2 antagonism of tie2 and initiates a positive feedback loop wherein FOXO1-driven ANG2 expression promotes vascular remodeling and leakage.
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Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2
Bo Hu,Ping Guo,Quan Fang,Huo Quan Tao,Degui Wang,Motoo Nagane,Hui Jein Su Huang,Yuji Gunji,Ryo Nishikawa,Kari Alitalo,Webster K. Cavenee,Shi Yuan Cheng +11 more
TL;DR: It is suggested that Ang2 plays a critical role in inducing tumor cell infiltration, and that this invasive phenotype is caused by activation of MMP-2.