K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro.
Imre Vastrik,Arja Kaipainen,T L Penttilä,A Lymboussakis,Riitta Alitalo,M Parvinen,Kari Alitalo +6 more
TL;DR: The pattern of mad expression in tissues and its ability to inhibit cell growth in vitro suggests that Mad can cause the cessation of cell proliferation associated with cell differentiation in vivo.
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Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.
Susan N. Thomas,Joseph M. Rutkowski,Miriella Pasquier,Emma L. Kuan,Kari Alitalo,Gwendalyn J. Randolph,Melody A. Swartz +6 more
TL;DR: Analysis of immune responses to dermal vaccination and contact hypersensitivity challenge in K14-VEGFR-3-Ig mice suggests that lymphatic drainage plays more important roles in regulating humoral immunity and peripheral tolerance than in effector T cell immunity.
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Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival
Linda Lorenz,Jennifer Axnick,Tobias Buschmann,Carina Henning,Sofia Urner,Shentong Fang,Harri Nurmi,Nicole Eichhorst,Richard Holtmeier,Kálmán Bódis,Jong-Hee Hwang,Karsten Müssig,Daniel Eberhard,Jörg Stypmann,Oliver Kuss,Michael Roden,Kari Alitalo,Dieter Häussinger,Eckhard Lammert +18 more
TL;DR: The findings uncover a signalling pathway in vascular endothelial cells that translates blood perfusion and mechanotransduction into organ growth and maintenance and release angiocrine signals that lead to hepatocyte survival and liver growth.
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A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development
Jacques A. Villefranc,Stefania Nicoli,Katie Bentley,Michael Jeltsch,Georgia Zarkada,John C. Moore,Holger Gerhardt,Kari Alitalo,Nathan D. Lawson +8 more
TL;DR: A mutation in zebrafish vegfc is identified that severely affects lymphatic development and leads to angiogenesis defects on sensitized genetic backgrounds and an autocrine Vegfc/Flt4 loop plays an important role in migratory persistence and filopodia stability during sprouting.
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The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Caroline A. Heckman,Tanja Holopainen,Maria Wirzenius,Salla Keskitalo,Michael Jeltsch,Seppo Ylä-Herttuala,Stephen R. Wedge,Juliane M. Jürgensmeier,Kari Alitalo +8 more
TL;DR: Cediranib may, therefore, be an effective means of preventing tumor progression, not only by inhibiting VEGFR-2 activity and angiogenesis, but also by concomitantly inhibition of VEG FR-3 activity and lymphangiogenesis.