K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium
Silvana Breiteneder-Geleff,Afschin Soleiman,Heinrich Kowalski,Reinhard Horvat,Gabriele Amann,Ernst Kriehuber,Katja Diem,Wolfgang Weninger,Erwin Tschachler,Kari Alitalo,Dontscho Kerjaschki +10 more
TL;DR: In this article, a light and electron microscopic immunohistochemistry (EMI) was used to detect podoplanin, a ∼38kd membrane glycoprotein of podocytes, specifically expressed in the endothelium of lymphatic capillaries, but not in the blood vasculature.
Journal ArticleDOI
Vascular endothelial growth factor‐C‐mediated lymphangiogenesis promotes tumour metastasis
Stefano J. Mandriota,Lotta Jussila,Michael Jeltsch,Amelia Compagni,Danielle Baetens,Remko Prevo,Suneale Banerji,Joachim Huarte,Roberto Montesano,David A. Jackson,Lelio Orci,Kari Alitalo,Gerhard Christofori,Michael S. Pepper +13 more
TL;DR: It is demonstrated that VEGF‐C‐induced lymphangiogenesis mediates tumour cell dissemination and the formation of lymph node metastases.
Journal ArticleDOI
Copy number variation and selection during reprogramming to pluripotency
Samer M.I. Hussein,Nizar N. Batada,Sanna Vuoristo,Reagan W. Ching,Reija Autio,Reija Autio,Elisa Närvä,Siemon Ng,Michel Sourour,Riikka H. Hämäläinen,Cia Olsson,Karolina Lundin,Milla Mikkola,Ras Trokovic,Michael Peitz,Oliver Brüstle,David P. Bazett-Jones,Kari Alitalo,Riitta Lahesmaa,Andras Nagy,Timo Otonkoski +20 more
TL;DR: It is shown that significantly more CNVs are present in early-passage human iPS cells than intermediate passage human i PS cells, fibroblast cell origins and with human embryonic stem (ES) cells.
Journal ArticleDOI
Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3
Daniel J. Dumont,Lotta Jussila,Jussi Taipale,Athina Lymboussaki,Tuija Mustonen,Katri Pajusola,Martin L. Breitman,Kari Alitalo +7 more
TL;DR: It is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos, indicating an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels.
Journal ArticleDOI
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Birgitta Olofsson,Katri Pajusola,Arja Kaipainen,G. von Euler,Vladimir Joukov,Olli Saksela,Arto Orpana,R F Pettersson,Kari Alitalo,Ulf Eriksson +9 more
TL;DR: The results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.