Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress.
Eleonora Iob,Andrew Steptoe +1 more
TLDR
The cardiovascular consequences of cortisol excess are outlined, the comprehensive overview of recent studies investigating the relationship of hair cortisol with CVD is provided, and clinical implications and limitations of the evidence are discussed.Abstract:
This review focuses on the concentration of cortisol in human hair as a biomarker of chronic stress in cardiovascular disease (CVD). We outline the cardiovascular consequences of cortisol excess and provide a comprehensive overview of recent studies investigating the relationship of hair cortisol with CVD. In addition, clinical implications and limitations of the evidence are discussed, together with directions for future research. Hair cortisol may be a reliable biomarker of chronic stress since it provides quantification of total cortisol secreted into hair over several weeks. A growing body of evidence suggests that elevated hair cortisol levels are associated with both the incidence of CVD and poorer recovery and treatment outcomes. Moreover, increased hair cortisol concentration has been linked with established cardiometabolic risk factors for CVD including high blood pressure, diabetes, and adiposity. Hair cortisol is a promising biomarker of chronic cortisol excess which may contribute to both the pathogenesis and prognosis of CVD. However, the current evidence relies on small-scale cross-sectional studies. Further research adopting longitudinal designs across larger samples of CVD patients and healthy participants is required to inform the development of novel evidence-based interventions.read more
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Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis.
TL;DR: SARS‐CoV‐2 coronavirus infection ranges from asymptomatic through to fatal COVID‐19 characterized by a ‘cytokine storm’ and lung failure and Vitamin D deficiency has been postulated as a determinant of severity.
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The association between adversity and hair cortisol levels in humans: A meta-analysis
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Rethinking minority stress: A social safety perspective on the health effects of stigma in sexually-diverse and gender-diverse populations
Lisa M. Diamond,Jenna Alley +1 more
TL;DR: In this article , the authors argue that insufficient social safety is a primary cause of stigma-related health disparities and a key target for intervention, because the chronic threat-vigilance fostered by insufficient safety has negative long-term effects on cognitive, emotional, and immunological functioning even when exposure to minority stress is low.
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The social ecology of childhood and early life adversity.
Marcela Lopez,Monica O. Ruiz,Cynthia R. Rovnaghi,Grace K-Y. Tam,Jitka Hiscox,Ian H. Gotlib,Donald A. Barr,Victor G. Carrion,Kanwaljeet J. S. Anand +8 more
TL;DR: In this article, the authors identify cortisol as a stress biomarker and posit that hair cortisol concentrations represent a summative and chronological record of children's exposure to adverse experiences and other contextual stressors, and investigate the robust interactions among adverse conditions, protective factors, genetic and epigenetic influences, environmental exposures, and social policy within the context of a child's developmental stages.
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Cancer and stress: NextGen strategies.
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TL;DR: Recent advances in the underlying mechanisms that are responsible for stress in promoting malignancies are discussed, providing approaches for NextGen pharmacological therapies, PBI and TCM to reduce the burden of tumorigenesis.
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Sepanlou,Edson Serván-Mori,Seyedmojtaba Seyedmousavi,Hosein Shabaninejad,Katya Anne Shackelford,Azadeh Shafieesabet,Mehdi Shahbazi,Amira Shaheen,Masood Ali Shaikh,Mehran Shams-Beyranvand,MohammadBagher Shamsi,Morteza Shamsizadeh,Kiomars Sharafi,Mehdi Sharif,Mahdi Sharif-Alhoseini,Rajesh Sharma,Jun She,Aziz Sheikh,Peilin Shi,Mekonnen Sisay Shiferaw,Mika Shigematsu,Rahman Shiri,Reza Shirkoohi,Ivy Shiue,Farhad Shokraneh,Mark G Shrime,Si Si,Soraya Siabani,Tariq Jamal Siddiqi,Inga Dora Sigfusdottir,Rannveig Sigurvinsdottir,Donald H. Silberberg,Diego Augusto Santos Silva,João Pedro Silva,Natacha Torres Da Silva,Dayane Gabriele Alves Silveira,Jasvinder A. Singh,Narinder Pal Singh,Prashant Singh,Virendra Singh,Dhirendra N Sinha,Karen Sliwa,Mari Smith,Badr Hasan Sobaih,Soheila Sobhani,Eugene Sobngwi,Samir Soneji,Moslem Soofi,Reed J D Sorensen,Joan B. Soriano,Ireneous N. Soyiri,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Vinay Srinivasan,Jeffrey D. Stanaway,Vladimir I. Starodubov,Vasiliki Stathopoulou,Dan J. Stein,Caitlyn Steiner,Leo G Stewart,Mark A. Stokes,Michelle L Subart,Agus Sudaryanto,Mu'awiyyah Babale Sufiyan,Patrick J Sur,Ipsita Sutradhar,Bryan L. Sykes,P N Sylaja,Dillon O Sylte,Cassandra Szoeke,Rafael Tabarés-Seisdedos,Takahiro Tabuchi,Santosh Kumar Tadakamadla,Ken Takahashi,Nikhil Tandon,Segen Gebremeskel Tassew,Nuno Taveira,Arash Tehrani-Banihashemi,Tigist Gashaw Tekalign,Merhawi Gebremedhin Tekle,Mohamad-Hani Temsah,Omar Temsah,Abdullah Sulieman Terkawi,Manaye Yihune Teshale,Belay Tessema,Gizachew Assefa Tessema,Kavumpurathu Raman Thankappan,Sathish Thirunavukkarasu,Nihal Thomas,Amanda G. Thrift,George D. Thurston,Binyam Tilahun,Quyen G. To,Ruoyan Tobe-Gai,Marcello Tonelli,Roman Topor-Madry,Anna E. Torre,Miguel Tortajada-Girbés,Mathilde Touvier,Marcos Roberto Tovani-Palone,Bach Xuan Tran,Khanh Bao Tran,Suryakant Tripathi,Christopher Troeger,Thomas Truelsen,Nu Thi Truong,Afewerki Gebremeskel Tsadik,Derrick Tsoi,Lorainne Tudor Car,E. Murat Tuzcu,Stefanos Tyrovolas,Kingsley N. Ukwaja,Irfan Ullah,Eduardo A. Undurraga,Rachel L Updike,Muhammad Usman,Olalekan A. Uthman,Selen Begüm Uzun,Muthiah Vaduganathan,Afsane Vaezi,Gaurang Vaidya,Pascual R. Valdez,Elena Varavikova,Tommi Vasankari,Narayanaswamy Venketasubramanian,Santos Villafaina,Francesco Saverio Violante,Sergey K Vladimirov,Vasily Vlassov,Stein Emil Vollset,Theo Vos,Gregory R. Wagner,Fasil Wagnew,Yasir Waheed,Mitchell T. Wallin,Judd L. Walson,Yanping Wang,Yuan-Pang Wang,Molla Mesele Wassie,Elisabete Weiderpass,Robert G. Weintraub,Fitsum Weldegebreal,Kidu Gidey Weldegwergs,Andrea Werdecker,Adhena Ayaliew Werkneh,T. Eoin West,Ronny Westerman,Harvey Whiteford,Justyna Widecka,Lauren B. Wilner,Shadrach Wilson,Andrea Sylvia Winkler,Charles Shey Wiysonge,Charles D.A. Wolfe,Shouling Wu,Yun-Chun Wu,Grant M A Wyper,Denis Xavier,Gelin Xu,Simon Yadgir,Ali Yadollahpour,Seyed Hossein Yahyazadeh Jabbari,Bereket Yakob,Lijing L. Yan,Yuichiro Yano,Mehdi Yaseri,Yasin Jemal Yasin,Gokalp Kadri Yentur,Alex Yeshaneh,Ebrahim M Yimer,Paul S. F. Yip,Biruck Desalegn Yirsaw,Engida Yisma,Naohiro Yonemoto,Gerald Yonga,Seok Jun Yoon,Marcel Yotebieng,Mustafa Z. Younis,Mahmoud Yousefifard,Chuanhua Yu,Vesna Zadnik,Zoubida Zaidi,Sojib Bin Zaman,Mohammad Zamani,Zohreh Zare,Ayalew Jejaw Zeleke,Zerihun Menlkalew Zenebe,Anthony Lin Zhang,Kai Zhang,Maigeng Zhou,Sanjay Zodpey,Liesl Zühlke,Mohsen Naghavi,Christopher J L Murray +1028 more
TL;DR: Non-communicable diseases comprised the greatest fraction of deaths, contributing to 73·4% (95% uncertainty interval [UI] 72·5–74·1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional causes accounted for 18·6% (17·9–19·6), and injuries 8·0% (7·7–8·2).
Journal ArticleDOI
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
Nadeem Sarwar,Pei Gao,Seshasai Srk.,Reeta Gobin,Stephen Kaptoge,E Di Angelantonio,Erik Ingelsson,Debbie A Lawlor,Elizabeth Selvin,Meir J. Stampfer,Stehouwer Cda.,Sarah Lewington,Lisa Pennells,Alexander M. W. Cargill Thompson,Naveed Sattar,Ian R. White,Kausik K. Ray,John Danesh +17 more
TL;DR: A meta-analysis of individual records of diabetes, fasting blood glucose concentration, and other risk factors in people without initial vascular disease from studies in the Emerging Risk Factors Collaboration found diabetes confers about a two-fold excess risk for a wide range of vascular diseases, independently from other conventional risk factors.