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Hydrogel Nanoparticles in Drug Delivery

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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.
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This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.

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Citations
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Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery

TL;DR: The results of this study establish mucin as a readily-available, chemically-versatile, naturally-biocompatible alternative to complex multifunctional synthetic polymers as building blocks in the design of biomaterials for sustained drug delivery.
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Chitosan as a Natural Copolymer with Unique Properties for the Development of Hydrogels

TL;DR: This review aimed to study the structure as well as the function of chitosan and its hydrogel properties, the process which shows in swelling behavior.
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Alginate Nanoformulation: Influence of Process and Selected Variables

TL;DR: This review highlights the most used and recent manufacturing techniques of alginate-based nanoparticulate delivery system, including emulsification/gelation complexation, layer-by-layer, spray drying, electrospray and electrospinning methods.
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Preparation and characterization of alginate-PVA-based semi-IPN: controlled release pH-responsive composites

TL;DR: The fabrication of chemically cross-linked polyvinyl alcohol-graft-poly(acrylic acid)/sodium alginate hydrogel as a semi-interpenetrating polymer network (SIPN) significantly improved the surface morphology of SIPN hydrogels, which corresponds to their improved swelling ability and mechanical strength.
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Diatoms Green Nanotechnology for Biosilica-Based Drug Delivery Systems.

TL;DR: The functionalization strategies of diatom micro/nanoparticles for improving their biophysical properties, such as cellular internalization and drug loading/release kinetics, are described and hybrid diatom-based devices with advanced properties for theranostics and targeted or augmented drug delivery applications is discussed.
References
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Journal ArticleDOI

Hydrogels for biomedical applications.

TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
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Environment-sensitive hydrogels for drug delivery

TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
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Hydrogels in pharmaceutical formulations.

TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal Article

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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