Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
Citations
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Interfacially-mediated oxygen inhibition for precise and continuous poly(ethylene glycol) diacrylate (PEGDA) particle fabrication.
TL;DR: In this article, the role of initial solution composition in determining the relative particle to droplet size ratio is reported, and is found to contribute through its influence on the polymerization rate as well as the diffusivity of oxygen.
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Transient modeling of the reversible response of the hydrogel to the change in the ionic strength of solutions
Fukun Lai,Hua Li +1 more
TL;DR: In this paper, a multi-effect-coupling ionic-strength-stimulus (MECis) model is presented for the transient analysis of the reversible kinetics of the ionic strength-sensitive hydrogel.
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Matrix metalloproteinase-sensitive hydrogel microparticles for pulmonary drug delivery of small molecule drugs or proteins
Emilie Secret,Kelsey E. Crannell,Stefan J. Kelly,Maria K. Villancio-Wolter,Jennifer S. Andrew +4 more
TL;DR: It is demonstrated that these microparticles are nontoxic and demonstrated their viability as a drug carrier by studying the encapsulation and release of three types of drugs: a hydrophobic, hydrophilic and protein-based drug.
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Vapor-based grafting of crosslinked poly(N-vinyl pyrrolidone) coatings with tuned hydrophilicity and anti-biofouling properties
TL;DR: This vapor-based grafting technique is expected to provide a practical means for imparting surface hydrophilicity and anti-biofouling properties to substrates regardless of their surface chemistry or geometry.
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Injectable polypeptide-engineered hydrogel depot for amplifying the anti-tumor immune effect induced by chemo-photothermal therapy
Xiao-Lin Hou,Xiang Dai,Jie Yang,Bin Zhang,Dong-Hui Zhao,Chao-Qing Li,Zhong-yuan Yin,Yuan-Di Zhao,Bo Liu +8 more
TL;DR: Results of in vivo therapy tests exhibited that the Ag2S QD/DOX/Bestatin@PC10ARGD hydrogel with laser irradiation could activate anti-tumor immune effects that inhibit the growth of primary tumors and distal lung metastatic nodules.
References
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Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
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Environment-sensitive hydrogels for drug delivery
Yong Qiu,Kinam Park +1 more
TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
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Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.