Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
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Hydrogel: Preparation, characterization, and applications: A review
TL;DR: A review of the literature concerning classification of hydrogels on different bases, physical and chemical characteristics of these products, and technical feasibility of their utilization is presented in this paper, together with technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process.
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Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
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Biomedical applications of hydrogels: A review of patents and commercial products
TL;DR: From Wichterle’s pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments.
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
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Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
TL;DR: This work presents a new generation of high-performance liquid chromatography platforms for selective separation of Na6(CO3) from Na4(SO4) through Na2SO4 and shows real-world applications in drug discovery and treatment of central nervous system disorders.
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Journal ArticleDOI
In vitro and in vivo evaluation of transdermal iontophoretic delivery of hydromorphone
TL;DR: The narcotic analgesic, hydromorphone, was delivered by constant-current iontophoresis from aqueous solution through excised pig and human skin and from a hydrogel formulation into domestic pigs, finding the delivery rate per unit current was similar for both pig andhuman skin, even though the passive fluxes differed by a factor of six.
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Pulsating pH-responsive nanogels.
TL;DR: A novel method is presented for the design of robust, sustained nanochemomechanical oscillators based on the switching of chemoresponsive nanogel beads between their collapsed and swollen state by coupling them to an appropriately chosen nonlinear reaction.
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Formation of biocompatible nanoparticles by self-assembly of enzymatic hydrolysates of chitosan and carboxymethyl cellulose.
TL;DR: The chitosan-carboxymethyl cellulose nanoparticles were stably suspended over 1 week even under low pH (pH 3.0), high ionic strength (NaCl 1 M), or low temperature (4 °C) conditions.
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Single molecular mechanics of a cholesterol-bearing pullulan nanogel at the hydrophobic interfaces
ImShik Lee,Kazunari Akiyoshi +1 more
TL;DR: The interaction forces of CHP nanogels to the hydrophobic HOPG (highly orientated pyrolytic graphite) or carbon-coated surfaces were measured and the debonding forces were shown to depend on the applied loading forces.
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Mass transport enhancement by ultrasound in non-degradable polymeric controlled release systems.
Ilana Lavon,Joseph Kost +1 more
TL;DR: It was found that drug release rates from polymeric matrices exposed to ultrasound, can be controlled by modifying parameters like: ultrasound frequency, molecular weight of the incorporated drug and structure of the polymeric matrix (size of pores in the network).