Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
Citations
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Biomimetic protein-based elastomeric hydrogels for biomedical applications
TL;DR: The recent accomplishments in the synthesis, fabrication and biomedical applications of protein-based elastomeric hydrogels such as elastin, resilin, agelliform spider silk and theirderivatives are reviewed.
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Control of size dispersity of chitosan biopolymer microparticles and nanoparticles to influence vaccine trafficking and cell uptake.
TL;DR: Structurally related surfactant molecules were exploited to generate chitosan emulsions to provide systematic variation in micelle radii of curvature and size, allowing the influence of particles size to be isolated in two in vivo studies relating biopolymer particle size to cellular uptake and trafficking to lymph nodes.
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Green synthesis of controlled size gold and silver nanoparticles using antioxidant as capping and reducing agent
TL;DR: The cytotoxicity assay against human fibroblast cell line (WI-38) for 24 h and 3-days showed that these engineered NPs were completely safe toward these cells, and could be considered promising supplementary targeting materials in future.
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Synthesis and characterization of glucocorticoid functionalized poly(N-vinyl pyrrolidone): a versatile prodrug for neural interface.
TL;DR: Neural culture showed that both the prodrug and its precursor polymer were nontoxic to neurons and did not alter the ability of neurons to maintain neurite extensions, reassuring further application of this prodrug to mitigate inflammation at the neural interface.
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Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses.
Neda Kordalivand,Elena Tondini,Chun Yin Jerry Lau,Tina Vermonden,Enrico Mastrobattista,Wim E. Hennink,Ferry Ossendorp,Cornelus F. van Nostrum +7 more
TL;DR: In this article, different synthetic long peptides (SLPs) containing the CTL and CD4+ T-helper (Help) epitopes were synthesized and covalently conjugated via disulfide bonds to the polymeric network of cationic dextran nanogels.
References
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Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
Journal ArticleDOI
Environment-sensitive hydrogels for drug delivery
Yong Qiu,Kinam Park +1 more
TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
Journal ArticleDOI
Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.