Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
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Hydrogel: Preparation, characterization, and applications: A review
TL;DR: A review of the literature concerning classification of hydrogels on different bases, physical and chemical characteristics of these products, and technical feasibility of their utilization is presented in this paper, together with technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process.
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Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
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Biomedical applications of hydrogels: A review of patents and commercial products
TL;DR: From Wichterle’s pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments.
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
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Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
TL;DR: This work presents a new generation of high-performance liquid chromatography platforms for selective separation of Na6(CO3) from Na4(SO4) through Na2SO4 and shows real-world applications in drug discovery and treatment of central nervous system disorders.
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Journal ArticleDOI
Polysaccharide colloidal particles as delivery systems for macromolecules.
TL;DR: This article reviews the approaches which have aimed to associate macromolecules to chitosan in the form of colloidal structures and analyzes the evidence of their efficacy in improving the transport of the associated molecule through mucosae and epithelia.
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Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery.
Lev Bromberg,Eyal S. Ron +1 more
TL;DR: 'Intelligent' amphiphilic copolymers emerge as a novel trend in the application of thermodynamically stable self-assembling lyophilic colloids to protein and peptide delivery.
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Solute Diffusion within Hydrogels. Mechanisms and Models
TL;DR: In this paper, various mathematical models derived to explain and predict solute diffusion in hydrogels are reviewed and tested against literature data, and it was determined that a scaling hydrodynamic model provided the best explanation for solutes diffusion.
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The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres.
Ruxandra Gref,Abraham J. Domb,P. Quellec,Torsten Blunk,Rainer H. Müller,Jean-Marc Verbavatz,Robert Langer +6 more
TL;DR: St sterically stabilized nanospheres were developed using amphiphilic diblock or multiblock copolymers and exhibited increased blood circulation times and reduced liver accumulation, depending on the coating polyethylene glycol molecular weight and surface density.
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Statistical Mechanics of Swelling of Network Structures
TL;DR: In this article, the entropy of swelling a network of any degree of connectivity, or functionality f, is derived in a manner which avoids these inaccuracies and corrects relationships for the partial molal-free energy of dilution, swelling equilibrium and the influence of deformation on swelling equilibrium.