Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
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Salicylic Acid-grafted Chitosan Oligosaccharide Nanoparticle for Paclitaxel Delivery:
TL;DR: A hydrotropic agent, salicylic acid (SA), was grafted to chitosan oligosaccharide (CSO) backbone to develop a CSO/SA conjugate.
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Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery.
TL;DR: The cumulative in vitro release profiles of surfactant-coated and uncoated nanogels were almost identical and showed acceptable performance, and the surfaces of the MTX-loaded nanogel were modified by polysorbate 80 for the purpose of brain targeting.
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Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway.
TL;DR: In the present work, novel berberine nano-colloids hydrogel (BNH) was prepared for improving wound healing of diabetic rats and molecular mechanism research revealed that BNH could inhibit the expression of NF-κB, TNF-a and IL-6, but increase theexpression of F VEGF, CD 31 and SMA by activating Sirt 1 which were benefit for wound healing for diabetic rats.
Journal ArticleDOI
Synthesis and biomedical applications of fluorescent nanogels
TL;DR: This review focused on the recent advances in the synthesis and biomedical applications of fluorescent nanogels that are doped with organic compounds, metal nanoparticles (NPs) and quantum dots (QDs).
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A 3D in vitro spheroid model as a way to study the mechanisms of electroporation.
L. Wasungu,Jean-Michel Escoffre,Jean-Michel Escoffre,A. Valette,A. Valette,Justin Teissié,Justin Teissié,Marie-Pierre Rols,Marie-Pierre Rols +8 more
TL;DR: This work exploited multicellular tumor spheroids as an ex vivo model of tumor to validate the spheroid model as a way to study electro-mediated gene delivery processes and reveals that even if cells can be efficiently permeabilized with electric fields, gene expression is by contrast limited to the external layers of cells.
References
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Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
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Environment-sensitive hydrogels for drug delivery
Yong Qiu,Kinam Park +1 more
TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
Journal ArticleDOI
Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.