Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
Citations
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Hydrogel: Preparation, characterization, and applications: A review
TL;DR: A review of the literature concerning classification of hydrogels on different bases, physical and chemical characteristics of these products, and technical feasibility of their utilization is presented in this paper, together with technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process.
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Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
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Biomedical applications of hydrogels: A review of patents and commercial products
TL;DR: From Wichterle’s pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments.
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
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Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
TL;DR: This work presents a new generation of high-performance liquid chromatography platforms for selective separation of Na6(CO3) from Na4(SO4) through Na2SO4 and shows real-world applications in drug discovery and treatment of central nervous system disorders.
References
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In vitro release behavior and stability of insulin in complexation hydrogels as oral drug delivery carriers.
Bumsang Kim,Nicholas A. Peppas +1 more
TL;DR: Hydrogels of P(MAA-co-MEG) prepared with an initial ratio of 1:4 MEG:MAA and P( MAA-g-EG) hydrogels containing PEG chains of molecular weights of 200 showed the greatest change in insulin release rate from acidic to basic pH solutions and the greatest protective effect for insulin in simulated GI tract conditions.
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Structure and stability of nanogel particles prepared by internal cross-linking of casein micelles
TL;DR: In this paper, a cross-linking of all caseins within the casein micelles with the enzyme transglutaminase creates nanogel particles consisting of a covalently linked casein network from which micellar calcium phosphate (MCP) can be removed without compromising structural integrity.
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Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents.
TL;DR: A polymeric micelle drug carrier system was applied to the targeting of an MRI (magnetic resonance imaging) contrast agent and the signal intensity of the tumor was enhanced 2.0-fold by the use of this contrast agent.
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Modeling of drug release from polymeric delivery systems--a review.
TL;DR: The spectrum of mathematical models that have been developed to describe drug release from polymeric controlled release systems are reviewed, and simple empirical or semi-empirical models and complex mechanistic models that consider diffusion, swelling, and erosion processes simultaneously are presented.
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In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels.
TL;DR: There is a moderate correlation between in vitro skin permeation and in vivo erythema responses of topically applied capsaicin and nonivamide and the correlation between drug amount in SC and skin ery thema test in vivo was observed.