Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
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Hydrogel: Preparation, characterization, and applications: A review
TL;DR: A review of the literature concerning classification of hydrogels on different bases, physical and chemical characteristics of these products, and technical feasibility of their utilization is presented in this paper, together with technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process.
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Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
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Biomedical applications of hydrogels: A review of patents and commercial products
TL;DR: From Wichterle’s pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments.
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
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Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
TL;DR: This work presents a new generation of high-performance liquid chromatography platforms for selective separation of Na6(CO3) from Na4(SO4) through Na2SO4 and shows real-world applications in drug discovery and treatment of central nervous system disorders.
References
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Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion-droplet coalescence technique and characterization.
TL;DR: Gd-nanoCPs might be useful as an i.t. injectable device for gadolinium neutron-capture therapy and their ability for long-term retention of Gd-DTPA in the tumor indicated that.
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Mesh size and diffusive characteristics of semicrystalline poly(vinyl alcohol) membranes prepared by freezing/thawing techniques
TL;DR: In this paper, a volume-based crystalline fraction of PVA on a wet basis varied from 0.052 to 0.116 and was a function of the degree of crystallinity.
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Poly(ethylene glycol)–polyethyleneimine NanoGel™ particles: novel drug delivery systems for antisense oligonucleotides
TL;DR: Antisense phosphorothioate oligonucleotides (SODN) specific to human mdr1 gene were incorporated in NanoGel™ particles and were found to effectively inhibit expression of P-glycoprotein (P-gp) efflux pump in MDR cell lines.
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Functionalized injectable hydrogels for controlled insulin delivery
Dai P. Huynh,Minh Khanh Nguyen,Bong Soo Pi,Min S. Kim,Su Young Chae,Kang C. Lee,Bong Sup Kim,Sung Wan Kim,Doo Sung Lee +8 more
TL;DR: The concept of this research is using poly(beta-amino ester) (PAE) as a duo-functional group for synthesis of the novel sensitive injectable hydrogel for controlled drug/protein delivery and the cumulative release of the protein from the complex gel was investigated in vitro with different methods.
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Insulin-Loaded Nanoparticles are Prepared by Alginate Ionotropic Pre-Gelation Followed by Chitosan Polyelectrolyte Complexation
TL;DR: Mild formulation conditions, optimum particle size range obtained, high insulin entrapment efficiency, and resistance to gastrointestinal release seem to be synergic and promising factors toward development of an oral insulin delivery form.