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Hydrogel Nanoparticles in Drug Delivery

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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.
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This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.

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Citations
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Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery

TL;DR: A high-throughput microfluidic process to fabricate colloidally stable aqueous nanoparticulate colloids with tunable sizes at 50-150 nm and narrow size distribution and dual stimuli-responsive degradation and excellent cellular uptake is reported.
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Encapsulation in lysozyme/A. Sphaerocephala Krasch polysaccharide nanoparticles increases stability and bioefficacy of curcumin

TL;DR: The results demonstrated that nanosized proteins/polysaccharides complex could be used to protect labile lipophilic compounds such as curcumin to enhance their bioavailability in vivo, supporting potential application of cur cumin-loaded proteins/ polysaccharide complex in functional foods.
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Improving sciatic nerve regeneration by using alginate/chitosan hydrogel containing berberine

TL;DR: Alg/Chit hydrogels can be applied as a treatment to heal peripheral nerve injuries and the in vivo results showed the positive effect of berberine especially the hydrogel contained 1% of berBERine on regeneration of sciatic nerve.
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Hydrogels in mucosal delivery

TL;DR: Nanosized hydrogel systems that make use of biological recognition or targeting motifs, by reacting to disease-specific environmental triggers and/or chemical signals to affect drug release, are now emerging as components of a new generation of therapeutics that promise improved residence time, faster response to stimuli and triggered release.
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Self-assembled thixotropic silver cluster hydrogel for anticancer drug release

TL;DR: This reaction avoids use of hydrogelators, crosslinkers or any exogenous toxic reducing agents, making it a facile and green method, in addition to reducing the organ toxicity.
References
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Journal ArticleDOI

Hydrogels for biomedical applications.

TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
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Environment-sensitive hydrogels for drug delivery

TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
Journal ArticleDOI

Hydrogels in pharmaceutical formulations.

TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal Article

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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