Journal ArticleDOI
Hydrogel Nanoparticles in Drug Delivery
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TLDR
Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.read more
Citations
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Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration
Guadalupe Abrego,Helen L. Alvarado,Eliana B. Souto,Bessy Guevara,Lyda Halbaut Bellowa,Alexander Parra,Ana C. Calpena,Maria Luisa García +7 more
TL;DR: Two optimized pranoprofen-loaded poly-l-lactic-co glycolic acid (PLGA) nanoparticles have been developed and further dispersed into hydrogels for the production of semi-solid formulations intended for ocular administration to improve the ocular biopharmaceutical profile of the selected non-steroidal anti-inflammatory drug.
Hydrogels as Drug Delivery Systems; Pros and Cons
TL;DR: Development of successful hydrogel based delivery system is possible upon knowledge about the hydrogels forming polymers physiochemical properties and understanding the influencing factors which control the swelling behaviors, hydrophilicity, biodegradability, biocompatibility and targetability of the selected polymer.
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Material solutions for delivery of CRISPR/Cas-based genome editing tools: Current status and future outlook
TL;DR: This review seeks to provide a comprehensive overview of different types of carriers ranging from classic drug delivery materials to advanced drug delivery systems that can transport CRISPR/Cas systems and mediate genome editing at the targeted loci.
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Gellan gum nanohydrogel containing anti-inflammatory and anti-cancer drugs: a multi-drug delivery system for a combination therapy in cancer treatment.
TL;DR: NH improved drug performances, acting as paclitaxel and prednisolone solubility enhancer and favoring the drug uptake in the cells, and allowed an increased cytotoxic effect in vitro on several types of cancer cells due to the synergistic effect of the combination of anti-inflammatory and anti-cancer drugs.
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Hydrogel-based phototherapy for fighting cancer and bacterial infection
TL;DR: This review presents recent advancements of hydrogel’s use in phototherapy applications by focusing on three kinds of phototherapeutic methods including photodynamic therapy (PDT), photothermal therapy (PTT), and phototherapy-containing combination therapy (PCCT).
References
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Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
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Environment-sensitive hydrogels for drug delivery
Yong Qiu,Kinam Park +1 more
TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
Journal ArticleDOI
Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.