Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Advances of nanotechnology in agro-environmental studies
TL;DR: Findings show that the use of nanomaterials can improve the quality of the environment and help detect and remediate polluted sites.
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Nonviral vectors for the delivery of small interfering RNAs to the CNS.
TL;DR: The different approaches that are being used to efficiently deliver genetic material to neuronal tissue using nonviral vectors, including the use of cationic lipids, polyethylenimine derivatives, dendrimers, carbon nanotubes and the combination of carbon-made nanoparticles with dendedrimers are covered.
Journal ArticleDOI
Ninety-day inhalation toxicity study with a vapor grown carbon nanofiber in rats.
Michael P. DeLorme,Yukihiro Muro,Toshihiro Arai,Deborah A. Banas,Steven R. Frame,Kenneth L. Reed,David B. Warheit +6 more
TL;DR: The results with CNF are compared with published findings of 90-day inhalation studies in rats with carbon nanotubes, and hypotheses are presented for potency differences based on CNT physicochemical characteristics.
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Gold nanoparticles enter rat ovarian granulosa cells and subcellular organelles, and alter in-vitro estrogen accumulation.
TL;DR: In insight into the toxicologic effects gold nanoparticles elicit on ovarian granulosa cells, it appeared that some intracellular organelles involved in steroidogenesis were infiltrated and/or altered due to the presence of the nanogold particles.
Journal ArticleDOI
The MTT and Crystal Violet Assays: Potential Confounders in Nanoparticle Toxicity Testing.
TL;DR: Findings strongly indicate that a careful choice of in vitro viability systems is required to avoid flawed measurement of NPs toxicity.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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