Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties
Nazanin R. Yacobi,Harish C. Phuleria,Lucas DeMaio,Chi H. Liang,Ching-An Peng,Constantinos Sioutas,Zea Borok,Kwang-Jin Kim,Edward D. Crandall +8 more
TL;DR: Investigation of the effects of ultrafine ambient particulate suspensions, polystyrene nanoparticles, quantum dots and single-wall carbon nanotubes on alveolar epithelial cell barrier properties indicates disruption of alveolars epithelial barrier properties likely involves alteration of cellular transport pathways and is dependent on specific nanoparticle composition, shape and/or surface charge.
Journal ArticleDOI
The Toxic Truth About Carbon Nanotubes in Water Purification: a Perspective View
TL;DR: A CNT safety clock is proposed that could form the basis of an acceptable CNTSafety guidelines and several new risk analysis roots and framework extrapolations from CNT-based water purification technologies are suggested.
Journal ArticleDOI
Single walled carbon nanotubes (SWCNT) affect cell physiology and cell architecture.
TL;DR: The effect on cell behaviour (cell proliferation, cell activity, cytoskeleton organization, apoptosis and cell adhesion) were dependent on cell type, SWCNT quality (purified or not) andSWCNT concentration.
Journal ArticleDOI
Different stabilities of multiwalled carbon nanotubes in fresh surface water samples.
TL;DR: This is a first systematic study examining the stability of carbon nanotubes in natural surface waters, the results from which will be useful for understanding the transport, fate and ecological effect of carbon Nanot tubes in the aqueous environment.
Journal ArticleDOI
In vitro evaluation of cytotoxicity of engineered carbon nanotubes in selected human cell lines.
TL;DR: The mechanism for causing cell death in this study was attributed to apoptosis and necrosis after physical penetration by CNTs and oxidative stress via formation of reactive oxygen species.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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