Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Nanotoxicology and nanoparticle safety in biomedical designs.
Jafar Ai,Esmaeil Biazar,Mostafa Jafarpour,Mohammad Montazeri,Ali Majdi,Saba Aminifard,Mandana Zafari,Hanie R Akbari,Hadi Rad +8 more
TL;DR: Most metal oxide nanoparticles show toxic effects, but no toxic effects have been observed with biocompatible coatings, which will be reviewed in this article.
Journal ArticleDOI
A new era of cancer treatment: carbon nanotubes as drug delivery tools.
TL;DR: The biomedical applications of CNTs are explored, with particular emphasis on their use as therapeutic platforms in oncology, amid the rapid advances in the development of nanotechnology-based materials.
Journal ArticleDOI
Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?
Anna A. Shvedova,Elena R. Kisin,Dale W. Porter,Dale W. Porter,Paul A. Schulte,Valerian E. Kagan,Bengt Fadeel,Vincent Castranova +7 more
TL;DR: Carbon nanotubes may have a place in the armamentarium for treatment and monitoring of cancer, infection, and other disease conditions, and close attention to safety issues is required to ensure that the opportunities that carbon nanot tubes and other engineered nanoparticles offer can be translated into feasible and safe constructs for the treatment of human disease.
BookDOI
Flame retardant polymer nanocomposites
TL;DR: In this article, the authors present an approach to evaluate the properties of polymer-carbon nanotube composites in terms of their ability to resist fire in an industrial setting.
Journal ArticleDOI
Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice
Nicklas Raun Jacobsen,Peter Møller,Keld Alstrup Jensen,Ulla Vogel,Ole Ladefoged,Steffen Loft,Håkan Wallin +6 more
TL;DR: The data suggest that ApoE-/- model is sensitive for evaluating particle induced inflammation and shows that instillation of CB was more toxic than inhalation of a presumed similar dose with respect to inflammation in the lungs of Apo E-/- mice.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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