Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Understanding the Toxicity of Carbon Nanotubes
TL;DR: Recent investigations into the basis of CNT toxicity carried out by the team and by other laboratories are highlighted, highlighting several important factors that explain the disparities in the experimental results of nanotoxicity, such as impurities, amorphous carbon, surface charge, shape, length, agglomeration, and layer numbers.
Journal ArticleDOI
Engineered nanoparticles in wastewater and wastewater sludge – Evidence and impacts
TL;DR: The present review attempts to link various compartmentalization aspects of the nanoparticles, their physical properties and toxicity in wastewater and wastewater sludge through simile drawn from other environmental streams.
Journal ArticleDOI
Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis
Anna A. Shvedova,Elena R. Kisin,Ashley R. Murray,Victor J. Johnson,Olga Gorelik,Sivaram Arepalli,Ann F. Hubbs,Robert R. Mercer,Phouthone Keohavong,Nancy B. Sussman,Jide Jin,Jinling Yin,Samuel Stone,Bean T. Chen,Gregory J. Deye,Andrew D. Maynard,Vincent Castranova,Vincent Castranova,Paul A. Baron,Valerian E. Kagan +19 more
TL;DR: SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice.
Journal ArticleDOI
Metal-based nanoparticles and their toxicity assessment.
Amanda M. Schrand,Mohammad F. Rahman,Saber M. Hussain,John J. Schlager,David A. Smith,Ali F. Syed +5 more
TL;DR: There are many challenges to overcome before the authors can determine if the benefits outweigh the risks associated with NPs, and some metal-based NPs are showing increased toxicity, even if the same material is relatively inert in its bulk form.
Journal ArticleDOI
Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles.
TL;DR: The results indicate that the differential surface-charge-dependent localization of nanoceria in normal and cancer cells plays a critical role in the nanoparticles' toxicity profile.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Anna A. Shvedova,Elena R. Kisin,Robert R. Mercer,Ashley R. Murray,Victor J. Johnson,Alla I. Potapovich,Yulia Y. Tyurina,Olga Gorelik,Sevaram Arepalli,Diane Schwegler-Berry,Ann F. Hubbs,James M. Antonini,Douglas E. Evans,Bon Ki Ku,Dawn Ramsey,Andrew D. Maynard,Valerian E. Kagan,Vincent Castranova,Vincent Castranova,Paul A. Baron +19 more