Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution.
Nalinikanth Kotagiri,Jin-Woo Kim +1 more
TL;DR: A holistic approach to the development of such “stealth” CNTs is presented, which encompasses not only several biophysicochemical factors that are not limited to surface treatment of C NTs, but also extraneous biological factors such as the protein corona formation that inevitably controls the in vivo fate of the particles.
Journal ArticleDOI
Recent Advances in Nanoparticle Preparation by Spray and Micro- emulsion Methods
TL;DR: Spray techniques are single-step methods of producing a broad spectrum of simple to multicomponent functional micro and nanoparticles and quantum dots and microemulsion methods are introduced.
Journal ArticleDOI
Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition.
Adriana Albini,Arianna Pagani,Laura Pulze,Antonino Bruno,Elisa Principi,Terenzio Congiu,Elisabetta Gini,Annalisa Grimaldi,Barbara Bassani,Silvio De Flora,Magda de Eguileor,Douglas M. Noonan +11 more
TL;DR: The data highlight the conclusion that, in a novel rodent model of exposure, MWCNTs may induce macrophage recruitment, activation, and amyloid deposition, causing potential damage to several organs.
Journal ArticleDOI
Two faces of carbon nanotube: toxicities and pharmaceutical applications.
Neha Gulati,Himanshu Gupta +1 more
TL;DR: In this review, different functionalization techniques of CNTs and their biomedical applications-in particular for cancer therapy to date-are reviewed in detail to present the potential of this nanovector.
Journal ArticleDOI
Integrated biomimetic carbon nanotube composites for in vivo systems.
Manoj K. Singh,José Grácio,Philip R. LeDuc,Paula Gonçalves,Paula A.A.P. Marques,Gil Gonçalves,Filipa Daniela Marques,Virgília S. Silva,Fernando Capela e Silva,Joana Reis,José Potes,Antonio C.M. Sousa +11 more
TL;DR: The highly successful capacity for in vivo implantation of a new carbon nanotube-based composite that is, itself, integrated with a hydroxyapatite-polymethyl methacrylate to create a nanocomposite is demonstrated.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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