Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Journal ArticleDOI
Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells.
Nicklas Raun Jacobsen,Giulio Pojana,Paul D. White,Peter Møller,Corey Alexander Cohn,Karen Smith Korsholm,Ulla Vogel,Antonio Marcomini,Steffen Loft,Håkan Wallin +9 more
TL;DR: It is indicated that SWCNT and C60 are less genotoxic in vitro than carbon black and diesel exhaust particles and that the mutant frequency in the cII gene was unaffected by 576 hr of exposure.
Journal ArticleDOI
A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics
Helinor Jane Johnston,Gary R Hutchison,Frans M Christensen,Sheona Peters,S. M. Hankin,Karin Aschberger,Vicki Stone +6 more
TL;DR: CNTs are a group of materials whose useful exploitable properties prompts their increased production and utilization within diverse applications, so that ensuring their safety is of vital importance.
Journal ArticleDOI
Environmental risks of nanotechnology: National Nanotechnology Initiative funding, 2000-2004.
TL;DR: The research priorities discussed by various interest groups concerned with the environmental risks of nanotechnology are analyzed, the distribution of federal environmental nanotechnology R&D funding is evaluated, and research in this field is discussed.
Journal ArticleDOI
The biocompatibility of nanodiamonds and their application in drug delivery systems.
Ying Zhu,Jing Li,Wenxin Li,Yu Zhang,Xiafeng Yang,Nan Chen,Yanhong Sun,Yun Zhao,Chunhai Fan,Qing Huang +9 more
TL;DR: An adsorption model for a variety of functional molecules on the ND clusters is proposed, which provides new ideas for developing a novel smart drug with various features such as sustained-release, targeting, and fluorescence imaging.
Journal ArticleDOI
Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo
Yoshinori Sato,Atsuro Yokoyama,Ken-ichiro Shibata,Yuki Akimoto,Shin Ichi Ogino,Yoshinobu Nodasaka,Takao Kohgo,Kazuchika Tamura,Tsukasa Akasaka,Motohiro Uo,Kenichi Motomiya,Balachandran Jeyadevan,Mikio Ishiguro,Rikizo Hatakeyama,Fumio Watari,Kazuyuki Tohji +15 more
TL;DR: The activation of the human acute monocytic leukemia cell line THP-1 in vitro and the response in subcutaneous tissue in vivo to CNTs of different lengths are investigated and results indicated that the degree of inflammation around 825-C NTs was stronger than that around 220-CNTs since macrophages could envelop 220- cNTs more readily.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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