Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
Reads0
Chats0
TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
More filters
Book ChapterDOI
Nanotoxicology: evaluating toxicity potential of drug-nanoparticles
TL;DR: This chapter has been drafted to describe some of the currently available techniques which may be industrially adopted for assessing the toxicological potential of drug loaded nanoparticles, including reproductive toxicity and genotoxicity assays.
Journal ArticleDOI
Directed and enhanced neurite outgrowth following exogenous electrical stimulation on carbon nanotube-hydrogel composites.
Mozhdeh Imaninezhad,Kyle Pemberton,Fenglian Xu,Kristin Kalinowski,Reetom Bera,Silviya P. Zustiak +5 more
TL;DR: The results indicate that nanocomposites, where carbon nanotubes have been added to hydrogel substrates, in combination with electrical stimulation provided improved conditions for neural growth and regeneration.
Journal ArticleDOI
Carbon nanotubes: An effective platform for biomedical electronics.
TL;DR: This review article comprehensively summarized recent trends in biomedical science and technologies utilizing a promising nanomaterial of CNTs in disease diagnosis and therapeutics, based on their biocompatibility and significance in drug delivery, implants, and bio imaging.
Journal ArticleDOI
Imaging methods for determining uptake and toxicity of carbon nanotubes in vitro and in vivo
Hannah C. Nerl,Crystal Cheng,Angela E. Goode,Shane D. Bergin,B Lich,Mhairi Gass,Alexandra E. Porter +6 more
TL;DR: The challenges associated with characterizing the toxicity of CNTs and the need for complimentary nanometrology techniques to relate their physicochemical properties to their toxicity are discussed.
Journal ArticleDOI
Acute and Subchronic Airway Inflammation after Intratracheal Instillation of Quartz and Titanium Dioxide Agglomerates in Mice
Martin Roursgaard,Keld Alstrup Jensen,Steen Seier Poulsen,Niels-Erik Jensen,Lars K. Poulsen,Maria Hammer,Gunnar Damgård Nielsen,Søren Thor Larsen +7 more
TL;DR: Differences were seen between the different polymorphs of nano-size TiO2, with rutileBeing the most inflammogenic and amorphous being the most potent in regard to acute tissue damage.
References
More filters
Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
Related Papers (5)
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Anna A. Shvedova,Elena R. Kisin,Robert R. Mercer,Ashley R. Murray,Victor J. Johnson,Alla I. Potapovich,Yulia Y. Tyurina,Olga Gorelik,Sevaram Arepalli,Diane Schwegler-Berry,Ann F. Hubbs,James M. Antonini,Douglas E. Evans,Bon Ki Ku,Dawn Ramsey,Andrew D. Maynard,Valerian E. Kagan,Vincent Castranova,Vincent Castranova,Paul A. Baron +19 more