Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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The Interaction of Manganese Nanoparticles with PC-12 Cells Induces Dopamine Depletion
Saber M. Hussain,Amanda K. Javorina,Amanda M. Schrand,Helen M. Duhart,Syed F. Ali,John J. Schlager +5 more
TL;DR: Results clearly demonstrate that nanoscale manganese can deplete DA, DOPAC, and HVA in a dose-dependent manner and further study is required to evaluate the specific intracellular distribution of Mn-40 nm nanoparticles, metal dissolution rates in cells and cellular matrices, and the propensity of Mn nanoparticles to cross the blood-brain barrier or be selectively uptaken by nasal epithelium.
Journal ArticleDOI
A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
TL;DR: This is the first study which has quantitatively determined and compared the cell uptake ratios and cytotoxicities of MWCNTs, GO and ND and it is demonstrated that ND exhibited the highest cell uptake ratio and the least cytotoxicity.
Journal ArticleDOI
Cell selective response to gold nanoparticles.
TL;DR: Gold nanoparticles induced death response in human carcinoma lung cell line A549, where the response was dose dependent and had a threshold effect, and the programmed nature of the death response is implied.
Journal ArticleDOI
Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice.
Sheng-Tao Yang,Xiang Wang,Guang Jia,Yiqun Gu,Tiancheng Wang,Haiyu Nie,Cuicui Ge,Haifang Wang,Yuanfang Liu +8 more
TL;DR: Although SWCNTs stayed in mice over 3 months, they showed low toxicity to mice and the decreasing glutathione (GSH) level and increasing malondialdehyde (MDA) level suggest that the toxicity of SWC NTs might be due to the oxidative stress.
Journal ArticleDOI
Carbon nanofibers and carbon nanotubes in regenerative medicine.
TL;DR: A review of the latest applications of carbon nanofibers and carbon nanotubes in regenerative medicine can be found in this article, where the authors focus on the application of carbon carbon nanostructures in the field of bio-inspired medicine.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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