Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Hazards and Risks of Engineered Nanoparticles for the Environment and Human Health
Danail Hristozov,Ineke Malsch +1 more
TL;DR: In this article, the relevance of each of the four steps of the risk assessment methodology was evaluated in the context of the current state of knowledge of the risks of nanomaterials, limitations were identified and recommendations were given on how to overcome them.
Journal ArticleDOI
Advances in mechanisms and signaling pathways of carbon nanotube toxicity.
TL;DR: Recent advances in CNT toxicology are summarized and discussed with a focus on the molecular interactions between CNT and mammalian systems, and the signaling pathways important for the development of CNT toxicity such as the NF-κB, NLRP3 inflammasome, TGF-β1, MAPK, and p53 signaling cascades.
Journal ArticleDOI
Surfactant effects on carbon nanotube interactions with human keratinocytes.
TL;DR: The results suggest that the surfactant-MWCNT interaction is more complex than simple dispersion alone and should be investigated to determine the mode of interaction.
Journal ArticleDOI
Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats.
Atsuro Yokoyama,Yoshinori Sato,Yoshinobu Nodasaka,Satoru Yamamoto,Takao Kawasaki,Masanobu Shindoh,Takao Kohgo,Tsukasa Akasaka,Motohiro Uo,Fumio Watari,Kazuyuki Tohji +10 more
TL;DR: Results showed that H-CNFs were not strong prophlogistic substances and were englobed in vivo, compared with other hat-stacked carbon nanofibers studied.
Journal ArticleDOI
Particle exposure levels during CVD growth and subsequent handling of vertically-aligned carbon nanotube films
Dhimiter Bello,A. John Hart,Kwangseog Ahn,Marilyn F. Hallock,Namiko Yamamoto,Enrique J. Garcia,Michael J. Ellenbecker,Brian L. Wardle +7 more
TL;DR: In this paper, the authors evaluate potential exposure to nanoscale particles during CVD growth of vertically-aligned CNTs in a university research lab, and during subsequent handling asthe CNT are removed from the furnace and detached fromthe growth substrate.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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