Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Reviewing the environmental and human health knowledge base of carbon nanotubes
TL;DR: There are different types of CNTs, and therefore they cannot be considered a uniform group of substances; and in environmental compartments, C NTs can be bioavailable to organisms and a possible accumulation along the food chain and high persistence.
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Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry
TL;DR: The current literature on pulmonary exposure to CNT/CNF and associated effects is summarized; recommendations and conclusions are provided that address test guideline modifications for rodent inhalation studies that will improve dosimetric extrapolation modeling for hazard and risk characterization based on the analysis of exposure-dose-response relationships.
Journal ArticleDOI
C60 binds to and deforms nucleotides.
TL;DR: The simulation results suggest that C60 molecules have potentially negative impact on the structure, stability, and biological functions of DNA molecules.
Journal ArticleDOI
Cancer-cell targeting and photoacoustic therapy using carbon nanotubes as "bomb" agents.
TL;DR: A unique approach using the large photoacoustic effect of single-walled carbon nanotubes (SWNTs) for targeting and selective destruction of cancer cells is demonstrated, and the laser power used for cancer killing is reduced 150-1500 times and the therapy efficiency is improved.
Journal ArticleDOI
Single-walled carbon nanotube-induced mitotic disruption
Linda M. Sargent,Ann F. Hubbs,Shih-Houng Young,Michael L. Kashon,Cerasela Zoica Dinu,Jeffrey L. Salisbury,Stanley A. Benkovic,David T. Lowry,Ashley R. Murray,Ashley R. Murray,Elena R. Kisin,Katelyn J. Siegrist,Lori A. Battelli,John Mastovich,Jacqueline L. Sturgeon,KL Bunker,Anna A. Shvedova,Anna A. Shvedova,Steven H. Reynolds +18 more
TL;DR: The results show significant disruption of the mitotic spindle by SWCNT at occupationally relevant doses and the increased proliferation that was observed in carbon nanotube-exposed cells indicates a greater potential to pass the genetic damage to daughter cells.
References
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Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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Anna A. Shvedova,Elena R. Kisin,Robert R. Mercer,Ashley R. Murray,Victor J. Johnson,Alla I. Potapovich,Yulia Y. Tyurina,Olga Gorelik,Sevaram Arepalli,Diane Schwegler-Berry,Ann F. Hubbs,James M. Antonini,Douglas E. Evans,Bon Ki Ku,Dawn Ramsey,Andrew D. Maynard,Valerian E. Kagan,Vincent Castranova,Vincent Castranova,Paul A. Baron +19 more