Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Functionalization, Dispersion, and Cutting of Boron Nitride Nanotubes in Water
TL;DR: In this article, high quality boron nitride nanotubes (BNNTs) were functionalized for the first time with water-soluble and biocompatible PEGylated phospholipid (mPEG-DSPE).
Journal ArticleDOI
Binding of pulmonary surfactant proteins to carbon nanotubes; potential for damage to lung immune defense mechanisms
Carolina Salvador-Morales,Paul A. Townsend,Emmanuel Flahaut,Catherine Vénien-Bryan,Alexis Vlandas,Malcolm L. H. Green,Robert B. Sim +6 more
TL;DR: It was shown that SP-A and SP-D selectively bind to carbon nanotubes, and the binding was Ca 2+ -ion dependent, and was variable between batches of nanot tubes, so it was likely to be mediated by surface impurities or chemical modifications of the Nanotubes.
Journal ArticleDOI
A strategy for assessing workplace exposures to nanomaterials
Gurumurthy Ramachandran,Michele L. Ostraat,Douglas E. Evans,Mark M. Methner,Patrick T. O'Shaughnessy,James B. D'Arcy,Charles L. Geraci,Edward Stevenson,Andrew D. Maynard,Keith Rickabaugh +9 more
TL;DR: This article provides useful guidance on conducting workplace characterization; understanding exposure potential to nanomaterials; accounting methods for background aerosols; constructing SEGs; and selecting appropriate instrumentation for monitoring, providing appropriate choice of exposure limits, and describing criteria by which exposure management decisions should be made.
Journal Article
On the cytotoxicity of carbon nanotubes
TL;DR: A lack of synergy among various issues while studying cytotoxicity and most developed paradigms for the mechanism of CNT toxicity is highlighted.
Journal ArticleDOI
Nanoparticles-a thoracic toxicology perspective.
TL;DR: Environmental nanoparticles provide a toxicological model for a new class of purposely 'engineered' NP arising from the nanotechnology industry, whose effects are much less understood and Bridging toxicological knowledge between the environmental nanoparticles and the new engineered nanoparticles is a considerable challenge.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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