Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Journal ArticleDOI
Airway Exposure to Silica-Coated TiO2 Nanoparticles Induces Pulmonary Neutrophilia in Mice
Elina M. Rossi,Lea Pylkkänen,Antti Joonas Koivisto,Minnamari Vippola,Minnamari Vippola,Keld Alstrup Jensen,Mirella Miettinen,Kristiina Sirola,Heli Nykäsenoja,Piia Karisola,Tuula Stjernvall,Esa Vanhala,Mirja Kiilunen,Pertti Pasanen,Maija Mäkinen,Kaarle Hämeri,Kaarle Hämeri,Jorma Joutsensaari,Timo Tuomi,Jorma Jokiniemi,Jorma Jokiniemi,Henrik Wolff,Kai Savolainen,Sampsa Matikainen,Harri Alenius +24 more
TL;DR: Interestingly, the level of lung inflammation could not be explained by the surface area of the particles, their primary or agglomerate particle size, or radical formation capacity but is rather explained byThe surface coating.
Journal ArticleDOI
Adverse Effects of Industrial Multiwalled Carbon Nanotubes on Human Pulmonary Cells
Lyes Tabet,Cyrill Bussy,Nadia Amara,Ari Setyan,Alain Grodet,Michel J. Rossi,Jean Claude Pairon,Jorge Boczkowski,Sophie Lanone +8 more
TL;DR: It is demonstrated that MWCNT produced for industrial purposes exert adverse effects without being internalized by human epithelial and mesothelial pulmonary cell lines.
Journal ArticleDOI
The effects of nanoparticles on mouse testis Leydig cells in vitro.
Tomoko Komatsu,Masako Tabata,Miyoko Kubo-Irie,Takahisa Shimizu,Kenichiro Suzuki,Yoshimasa Nihei,Ken Takeda +6 more
TL;DR: It was found that DEPs, TiO(2) and CB nanoparticles were taken up by Leydig cells, and affected the viability, proliferation and gene expression, and the patterns were unique for each nanoparticle.
Journal ArticleDOI
Nanotoxicology--a pathologist's perspective.
Ann F. Hubbs,Robert R. Mercer,Stanley A. Benkovic,Jack R. Harkema,Krishnan Sriram,Diane Schwegler-Berry,Madhusudan P. Goravanahally,Timothy R. Nurkiewicz,Vincent Castranova,Linda M. Sargent +9 more
TL;DR: The size and physiochemical properties of nanoparticulates affect bioactivity is important in assuring that the exciting new products of nanotechnology are used safely.
Journal ArticleDOI
A review on technological aspects influencing commercialization of carbon nanotube sensors
Derrick Wen Hui Fam,Al. Palaniappan,Alfred Iing Yoong Tok,Bo Liedberg,Shabbir Moochhala,Shabbir Moochhala +5 more
TL;DR: Carbon nanotubes (CNTs) are one of the advanced functional materials of today and has been researched extensively since its discovery as discussed by the authors. But despite intensive research, commercialization of these potential applications still remains elusive mainly due to the lack of control in synthesis of specific chirality, diameter and length of CNTs, which influences device performance.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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