Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Titanium dioxide nanoparticles induce emphysema-like lung injury in mice
Huei-Wen Chen,Sheng-Fang Su,Chiang Ting Chien,Wei Hsiang Lin,Sung-Liang Yu,Cheng-Chung Chou,Jeremy J.W. Chen,Pan-Chyr Yang +7 more
TL;DR: Results indicated that nanoTiO2 can induce severe pulmonary emphysema, which may be caused by activation of PlGF and related inflammatory pathways.
Journal ArticleDOI
Effects of various physicochemical characteristics on the toxicities of ZnO and TiO2 nanoparticles toward human lung epithelial cells
I-Lun Hsiao,Yuh-Jeen Huang +1 more
TL;DR: It is found that smaller NPs had greater toxicity than larger ones--a finding that differs from those of previous studies, and the phase of the NPs can also play an important role under size-, surface area-, and shape-controlled conditions.
Journal ArticleDOI
Carbon nanotubes for biomedical imaging: The recent advances ☆
Hua Gong,Rui Peng,Zhuang Liu +2 more
TL;DR: CNTs are unique imaging probes with great potential in biomedical multimodal imaging, when labeled with radioactive isotopes, many groups have developed nuclear imaging with functionalized CNTs.
Journal ArticleDOI
Review Article: PharmacologyEmerging nanopharmaceuticals
TL;DR: This review will provide a brief discussion of the major nanopharmaceutical formulations as well as the impact of nanotechnology into the future.
Journal ArticleDOI
Reactivity of carbon nanotubes: free radical generation or scavenging activity?
Ivana Fenoglio,Maura Tomatis,Dominique Lison,Julie Muller,Antonio Fonseca,Janos B. Nagy,Bice Fubini +6 more
TL;DR: It is reported that multiwall carbon nanotubes (MWCNT) in aqueous suspension do not generate oxygen or carbon-centered free radicals in the presence of H2O2 or formate, respectively, as detected with the spin-trapping technique.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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