Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Potential in vitro effects of carbon nanotubes on human aortic endothelial cells.
Valerie G. Walker,Zheng Li,Tracy Hulderman,Diane Schwegler-Berry,Michael L. Kashon,Petia P. Simeonova +5 more
TL;DR: Overall, the results indicate that SWCNT and MWCNT exposure induce direct effects on endothelial cells in a dose-dependent manner.
Journal ArticleDOI
Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model
Tina M. Sager,Michael W. Wolfarth,Michael E. Andrew,Ann F. Hubbs,Sherri Friend,Teh-hsun Chen,Dale W. Porter,Nianqiang Wu,Feng Yang,Raymond F. Hamilton,Andrij Holian +10 more
TL;DR: The results suggest that in vivo pathogenicity of the BMWCNT and FMWCNT correlates with activation of the NLRP3 inflammasome in the lung.
Journal ArticleDOI
Single-wall carbon nanotube nanobomb agents for killing breast cancer cells
Balaji Panchapakesan,Shaoxin Lu,Kousik Sivakumar,Kasif Taker,Gregory Cesarone,Eric Wickstrom +5 more
TL;DR: In this article, single-wall carbon nanotubes (SWCNT) were used as potent therapeutic nanobomb agents for killing breast cancer cells, which can potentially outperform most nanotechnological approaches in killing cancer cells without toxicity.
Journal ArticleDOI
Human health effects of residual carbon nanotubes and traditional water treatment chemicals in drinking water.
Geoffrey S. Simate,Sunny E. Iyuke,Sehliselo Ndlovu,Michael David Heydenrych,Lubinda F. Walubita +4 more
TL;DR: A qualitative comparison of the human health effects of both residual CNTs and traditional water treatment chemicals is given in this paper because they are both used for water treatment and purification.
Journal ArticleDOI
Immunotoxicity of nanoparticles: a computational study suggests that CNTs and C60 fullerenes might be recognized as pathogens by Toll-like receptors
M. A. Turabekova,Bakhtiyor Rasulev,M. Theodore,J. Jackman,Danuta Leszczynska,Jerzy Leszczynski +5 more
TL;DR: A hypothetical model providing the potential mechanistic explanation for immune and inflammatory responses observed upon exposure to carbon nanoparticles is suggested and strengthened by the indirect experimental findings indicating that CNTs and fullerenes induce an excessive expression of specific cytokines and chemokines (i.e. IL-8 and MCP1).
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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