Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Carbon Nanotubes: their Potential and Pitfalls for Bone Tissue Regeneration and Engineering
TL;DR: The status and potential applications of carbon nanotubes in bone tissue engineering are described and an examination of how the different properties of carbon Nanotubes affect tissue growth, how these properties might be leveraged in regenerative tissue therapies and how impurities or contaminates affect their toxicity and biological interaction are evaluated.
Journal ArticleDOI
In vivo immunological toxicity in mice of carbon nanotubes with impurities
Shozo Koyama,Yoon Ahm Kim,Takuya Hayashi,Kenji Takeuchi,Chifumi Fujii,Naomi Kuroiwa,Haruhide Koyama,Tamotsu Tsukahara,Morinobu Endo +8 more
TL;DR: The studies suggest that such high-temperature thermal treatment is an effective way to improve the biocompatibility of carbon nanotube.
Journal ArticleDOI
Multi-walled carbon nanotubes (MWCNT): induction of DNA damage in plant and mammalian cells.
TL;DR: Genotoxic responses such as chromosomal aberrations and DNA strand breakages were studied in Allium cepa, human lymphocytes, mouse bone marrow cells and pBR322 plasmid DNA, and MWCNT may have significant impact on genomic activities.
Journal ArticleDOI
Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice
Haiyan Tong,John K. McGee,Rajiv K. Saxena,Urmila P. Kodavanti,Robert B. Devlin,M. Ian Gilmour +5 more
TL;DR: This study indicates that while acid functionalization increases the pulmonary toxicity of both UFCB and SWCNTs, this treatment caused cardiac effects only with the AF-carbon nanotubes.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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