Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Exploring the Immunotoxicity of Carbon Nanotubes
TL;DR: Some existing studies assessing carbon nanotubes’ toxicity to immune system are reviewed, and the potential mechanistic explanation is provided.
Journal ArticleDOI
Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis
TL;DR: Aberrant activations of TGF-β/p-Smad2 and β-catenin are postulated to induce EMT during SWCNT-induced pathogenic fibrosis, which contributes significantly to fibroblast expansion.
Journal ArticleDOI
Carbon Nanotubes: Solution for the Therapeutic Delivery of siRNA?
D. Lynn Kirkpatrick,Michelle Weiss,Anton V. Naumov,Geoffrey Bartholomeusz,R. Bruce Weisman,Olga Gliko +5 more
TL;DR: Recent data suggest single-walled carbon nanotubes are an excellent option for the delivery of siRNA clinically and may become universal transfection vehicles for siRNA and other RNAs for therapeutic applications.
Journal ArticleDOI
Pulmonary toxicity and fibrogenic response of carbon nanotubes
TL;DR: This review discusses major cellular and molecular events governing pulmonary fibrosis, the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis.
Journal ArticleDOI
The role of atmospheric transformations in determining environmental impacts of carbonaceous nanoparticles.
Andrea J. Tiwari,Linsey C. Marr +1 more
TL;DR: The objective of this paper is to show that atmospheric transformations, often overlooked, have the potential to alter nanoparticles' physical and chemical properties and thus influence their environmental fate and impact.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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