Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Single-wall carbon nanotubes assisted photothermal cancer therapy: animal study with a murine model of squamous cell carcinoma.
TL;DR: The objective of this study is to validate the hypothesis that intratumoral injected SWNTs can absorb 785 nm near IR laser light and generate significant local hyperthermia to destroy tumors.
Journal ArticleDOI
Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment
Lei Zhang,Yecheng Li,Jimmy C. Yu +2 more
TL;DR: The surface modifications of nanostructures to achieve systematic targeting to intended sites and controlled release by different stimuli, including pH, redox, light, enzyme and so on are summarized.
Journal ArticleDOI
Comparative Proteomics and Pulmonary Toxicity of Instilled Single Walled Carbon Nanotubes, Crocidolite Asbestos and Ultrafine Carbon Black in Mice
Justin G. Teeguarden,Bobbie-Jo M. Webb-Robertson,Katrina M. Waters,Ashley R. Murray,Elena R. Kisin,Susan M. Varnum,Jon M. Jacobs,Joel G. Pounds,Richard C. Zanger,Anna A. Shvedova +9 more
TL;DR: Two high-sensitivity markers of inflammation, one (S100a9) observed in humans exposed to AB, were found and may be promising biomarkers of human response to SWCNT exposure, further evidence of broad similarity in the tissue-level response to AB.
Journal ArticleDOI
Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells
TL;DR: A novel, high throughput method to measure cellular uptake of CNT using turbimetry is described, which revealed that MWCNT activated NF-κB, enhanced phosphorylation of MAP kinase pathway components, and increased production of proinflammatory cytokines in human bronchial epithelial cells.
Journal ArticleDOI
In vivo imaging of carbon nanotube biodistribution using magnetic resonance imaging.
Achraf Al Faraj,Katarzyna Cieslar,Ghislaine Lacroix,Sophie Gaillard,Emmanuelle Canet-Soulas,Yannick Crémillieux +5 more
TL;DR: The presence of SWCNTs with associated metal impurity can be detected in vivo by noninvasive MR techniques and Histological analysis confirms the absence of SW CNTs in systemic organs when SWC NTs were intrapulmonary instilled.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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