Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Journal ArticleDOI
Preliminary results on the pathogenic effects of intratracheal exposure to one-dimensional nanocarbons
Hanna Grubek-Jaworska,Patrycja Nejman,K. Czumińska,Tadeusz Przybyłowski,Andrzej Huczko,Hubert Lange,Michał Bystrzejewski,P. Baranowski,Ryszarda Chazan +8 more
TL;DR: The results indicate that exposure on intratracheally introduced carbon nanotubes/nanofibers may induce measurable pulmonary pathology.
Journal ArticleDOI
Integrated Analysis of Dysregulated ncRNA and mRNA Expression Profiles in Humans Exposed to Carbon Nanotubes.
Anna A. Shvedova,Anna A. Shvedova,Naveena Yanamala,Elena R. Kisin,Timur O. Khailullin,Timur O. Khailullin,M. Eileen Birch,Liliya M. Fatkhutdinova +7 more
TL;DR: This study is the first to investigate aberrant changes in mRNA and ncRNA expression profiles in the blood of humans exposed to multi-walled carbon nanotubes, and reveals MWCNT potential to trigger pulmonary and cardiovascular effects as well as carcinogenic outcomes in humans.
Journal ArticleDOI
Multi-Walled Carbon Nanotube-Induced Gene Expression in the Mouse Lung: Association with Lung Pathology
Maricica Pacurari,Yong Qian,Dale W. Porter,Michael W. Wolfarth,Ying Wooi Wan,Dajie Luo,Min Ding,Vincent Castranova,Vincent Castranova,Nancy Lan Guo +9 more
TL;DR: It is identified that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs, including several carcinogenic-related signaling pathways and carcinogenesis itself.
Journal ArticleDOI
Nanotechnology and its use in imaging and drug delivery (Review)
Serjay Sim,Nyet Kui Wong +1 more
TL;DR: An overview of the recent advances of nanotechnology in the aspects of imaging and drug delivery can be found in this paper, where the authors provide an overview of some of the most common common diseases, including cardiovascular diseases and cancer.
Journal ArticleDOI
Response of Soil Microorganisms to As-Produced and Functionalized Single-Wall Carbon Nanotubes (SWNTs)
Zhong-Hua Tong,Marianne Bischoff,Loring Nies,Phillip R. Myer,Bruce Applegate,Ronald F. Turco +5 more
TL;DR: Results show that repeated applications of AP-SWNTs can affect microbial community structures and induce minor changes in soil metabolic activity in the low organic matter systems, and suggest that sorption to soil organic matter plays a controlling role in the soil microbiological responses to these nanomaterials.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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