Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Mechanisms underlying nano-sized air-pollution-mediated progression of atherosclerosis: carbon black causes cytotoxic injury/inflammation and inhibits cell growth in vascular endothelial cells.
Hideyuki Yamawaki,Naoharu Iwai +1 more
TL;DR: The present results demonstrate for the first time that CB directly affects the endothelium, causing cytotoxic injury, inflammatory responses, and inhibition of cell growth.
Journal ArticleDOI
Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges
Helinor Jane Johnston,Giulio Pojana,Stefano Zuin,Nicklas Raun Jacobsen,Peter Møller,Steffen Loft,Manuela Semmler-Behnke,Catherine McGuiness,Dominique Balharry,Antonio Marcomini,Håkan Wallin,Wolfgang G. Kreyling,Ken Donaldson,Lang Tran,Vicki Stone +14 more
TL;DR: This review identifies the challenges that exist within the assessment of NM risk and reflects on what commonly encountered challenges exist and explored how these issues may be resolved.
Journal ArticleDOI
An evaluation of the impact of multiwalled carbon nanotubes on soil microbial community structure and functioning
Babina Shrestha,Veronica Acosta-Martinez,Stephen B. Cox,Micah J. Green,Shibin Li,Jaclyn E. Cañas-Carrell +5 more
TL;DR: The results suggest a shift in soil microbial community composition to more tolerant microbial populations in the presence of extremely high MWNT concentrations, possibly due to metal or carbon impurities.
Journal ArticleDOI
Occupational Nanosafety Considerations for Carbon Nanotubes and Carbon Nanofibers
TL;DR: Evidence indicates that engineering controls and personal protective equipment can significantly decrease workplace exposure to CNTs and CNFs, and it appears prudent to develop prevention strategies to minimize workplace exposure.
Journal ArticleDOI
Research progress on siRNA delivery with nonviral carriers.
Yan Gao,Xinling Liu,Xiao-Rong Li +2 more
TL;DR: Aside from liposomes, nanoparticles and cationic polymer carriers have exhibited improved in vivo stability, better biocompatibility, and efficiency for gene silencing with less cellular toxicity, and may represent a promising strategy for siRNA-based therapies, especially as nanomaterials.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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