Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes
Paola Tucci,Paola Tucci,Giovanni Porta,Massimiliano Agostini,David Dinsdale,Ivo Iavicoli,Kelvin Cain,Alessandro Finazzi-Agrò,Gerry Melino,Gerry Melino,Anne E. Willis +10 more
TL;DR: The data show that although TiO2 does not affect cell cycle phase distribution, nor cell death, these nanoparticles have a considerable and rapid effect on mitochondrial function, consistent with a specific role of mitochondria in this response.
Journal ArticleDOI
A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro
Tina Thurnherr,Christina Brandenberger,Kathrin Fischer,Liliane Diener,Pius Manser,Xenia Maeder-Althaus,Jean-Pierre Kaiser,Harald F. Krug,Barbara Rothen-Rutishauser,Peter Wick +9 more
TL;DR: It is demonstrated that despite the high potential for ROS formation, pristine MWCNTs can accumulate and persist within cells without having major long-term consequences or inducing adaptive mechanisms.
Journal ArticleDOI
Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation.
TL;DR: Pulmonary and systemic immune responses induced by intratracheal instillation of multi-walled carbon nanotubes (MWCNTs) were investigated in mice and it is suggested that MWCNTs may induce allergic responses in mice through B cell activation and production of IgE.
Journal ArticleDOI
Single-walled carbon nanotubes in biomedical imaging
TL;DR: A review of the latest developments in using single-walled carbon nanotubes (SWNTs) for biomedical imaging can be found in this paper, where a number of unique intrinsic optical properties have been widely used as contrast agents in Raman imaging, near-infrared (NIR) fluorescence imaging and photoacoustic imaging in vitro and in vivo.
Journal ArticleDOI
The significance of nanoparticles in particle-induced pulmonary fibrosis.
James D. Byrne,John A. Baugh +1 more
TL;DR: The severity of toxicological consequences warrants further examination of the effects of nanoparticles in humans, possible treatments and increased regulatory measures.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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