Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Poly(vinyl alcohol)/halloysite nanotubes bionanocomposite films: Properties and in vitro osteoblasts and fibroblasts response.
TL;DR: In vitro fibroblasts response demonstrated that both neat PVA and P VA/HNTs nanocomposite films were biocompatible and PVA/H NTs films favored to fibro Blasts attach and growth below 7.5 wt % of HNTs incorporated.
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In vivo Imaging and Drug Storage by Quantum-Dot-Conjugated Carbon Nanotubes
Yan Guo,Donglu Shi,Donglu Shi,Hoonsung Cho,Zhongyun Dong,Amit S. Kulkarni,Giovanni M. Pauletti,Wei Wang,Jie Lian,Wen Liu,Lei Ren,Qiqing Zhang,Guokui Liu,Christopher Huth,Lumin Wang,Rodney C. Ewing +15 more
TL;DR: The in vivo distribution determined by inductively coupled plasma mass spectrometry (ICP‐MS) indicates CNT‐QD uptake in various organs of live animals indicating in vivo imaging of live mice is achieved by intravenously injecting quantum dot (QD)‐conjugated CNT for the first time.
Journal ArticleDOI
Nanotechnology and nanotoxicology: a primer for clinicians.
TL;DR: The field of nanotoxicology is still in its infancy, however, with very limited literature regarding potential health effects and it has been proposed that dermal exposure will be the most relevant route of exposure, but there is considerably less literature regarding dermal effects and absorption.
Journal ArticleDOI
Perturbation of physiological systems by nanoparticles
TL;DR: This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies.
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The carcinogenic potential of nanomaterials, their release from products and options for regulating them.
TL;DR: It is concluded that the potential carcinogenic risk of nanomaterials can currently be assessed only on a case-by-case basis and that new standardised test methods need to be developed or existing ones adapted at the very least to achieve valid answers regarding the carcinogenic potential.
References
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Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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