Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Effect of Alkylation on the Cellular Uptake of Polyethylene Glycol-Coated Gold Nanoparticles.
Lok Wai Cola Ho,Wing-Yin Yung,Kwun Hei Samuel Sy,Ho Yin Li,Chun Kit K. Choi,Ken Cham-Fai Leung,Thomas W. Y. Lee,Chung Hang Jonathan Choi +7 more
TL;DR: The effect of alkylation on the cellular uptake of densely polyethylene glycol-coated nanoparticles, which are characterized by their limited entry into mammalian cells are reported, and insights into the incorporation ofAlkyl groups for designing bionanomaterials for cellular uptake and cytosolic accumulation with intracellular stability are offered.
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Quantum dots induced monocyte chemotactic protein-1 expression via MyD88-dependent Toll-like receptor signaling pathways in macrophages.
TL;DR: Findings indicate that, depending on their surface modification, OD705s activate MyD88 dependent-TLRs at the surface or inside of the cells, which is an important mechanism for nanoparticles-induced inflammatory responses.
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Identifying and Predicting Biological Risks Associated With Manufactured Nanoparticles in Aquatic Ecosystems
Tyson J. MacCormack,Greg G. Goss +1 more
TL;DR: In this article, the use of advanced analytical techniques, such as functional genomics, proteomics, and metabolomics, can provide a global assessment of the biological response to a novel chemical and will be important in determining the potential toxicity of nanoparticles.
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Identification of the main exposure scenarios in the production of CNT-polymer nanocomposites by melt-moulding process
D. Fleury,João A. S. Bomfim,Alexis Vignes,Clément Girard,Sébastien Metz,Felipe Muñoz,Badr R'Mili,Aurélien Ustache,Arnaud Guiot,Jacques Bouillard +9 more
TL;DR: In this article, the main hazards flows that could lead to a release of nanoparticles at workplace (exposure) have been identified, and some recommendations have been proposed to lower the risks of nanoparticle exposure during melt-moulding processes.
Journal ArticleDOI
Evaluation of oxidative stress and anti-oxidant status in rat serum following exposure of carbon nanotubes.
A. Rama Narsimha Reddy,M. Venkateswar Rao,Devarakonda R. Krishna,Devarakonda R. Krishna,V. Himabindu,Y. Narsimha Reddy +5 more
TL;DR: Results indicate that, exposure of multi wall carbon nanotubes induces oxidative stress by reducing the total anti-oxidant capacity in rats, and suggest possible occupational health hazard in chronic exposures.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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