Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
Oxidation reactions mediated by single-walled carbon nanotubes in aqueous solution.
Lei Ren,Wenwan Zhong +1 more
TL;DR: The unmodified or carboxylated SWCNT acted as both the oxidants and the catalysts in reactions, and accelerated the oxidation reactions mediated by horseradish peroxidase, a representative member of the enzyme family actively involved in balancing oxidative stress.
Journal ArticleDOI
Biological oxidative damage by carbon nanotubes: Fingerprint or footprint?
TL;DR: The decrease of antioxidant capacity, defined as biological oxidative damage (BOD), of CNTs-exposed serum is determined and the mBOD and sBOD may be useful denominators of surface activity and impurity content and assist in designing safer CNT’s.
Journal ArticleDOI
Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design
Arianna Gazzi,Arianna Gazzi,Laura Fusco,Marco Orecchioni,Marco Orecchioni,Silvia Ferrari,Giulia Franzoni,J. Stephen Yan,Matthias Rieckher,Guotao Peng,Matteo Andrea Lucherelli,Isabella Anna Vacchi,Ngoc Do Quyen Chau,Alejandro Criado,Akcan Istif,Donato Mancino,Antonio Dominguez,Hagen Eckert,Ester Vázquez,Tatiana Da Ros,Paola Nicolussi,Vincenzo Palermo,Bjoern Schumacher,Gianaurelio Cuniberti,Yiyong Mai,Cecilia Clementi,Matteo Pasquali,Xinliang Feng,Kostas Kostarelos,Açelya Yilmazer,Davide Bedognetti,Bengt Fadeel,Maurizio Prato,Maurizio Prato,Alberto Bianco,Lucia Gemma Delogu,Lucia Gemma Delogu +36 more
TL;DR: In this paper, the European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to develop a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other carbon-based materials (CBMs).
Journal ArticleDOI
Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X7 Receptor
TL;DR: It was concluded that Ni2+ impededSWCNT exocytosis by inhibiting P2X7R, leading to higher intracellular retention of SWCNTs and elevated cytotoxicity.
Journal ArticleDOI
The cardiac effects of carbon nanotubes in rat.
Mina Hosseinpour,Vahid Azimirad,Maryam Alimohammadi,Parviz Shahabi,Mina Sadighi,Ghazaleh Ghamkhari Nejad +5 more
TL;DR: Results of the HRV analysis showed that CNTs increased the heart rate but generally these nanomaterials did not cause serious problem in autonomic nervous system (ANS) normal activities.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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