Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
Reads0
Chats0
TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
More filters
Journal ArticleDOI
Carbon nanotubes in drug delivery: focus on infectious diseases.
Yitzhak Rosen,Noel M. Elman +1 more
TL;DR: This review focuses on the characterization, development, integration and application of carbon nanotubes as nanocarrier-based delivery systems and their appropriate design for achieving the desired drug delivery results in the different areas of infectious diseases.
Journal ArticleDOI
Pulmonary and systemic responses of highly pure and well-dispersed single-wall carbon nanotubes after intratracheal instillation in rats.
TL;DR: The histopathological findings in the lungs of rats exposed toSWCNTs showed inflammatory responses related with the vital reaction to the foreign substance that was instilled intratracheally, and there were no fibrosis, atypical lesion, or tumor-related findings even at the highest dose of SWCNT-exposed groups up to 6 months after instillation.
Journal ArticleDOI
Do Goethite Surfaces Really Control the Transport and Retention of Multi-Walled Carbon Nanotubes in Chemically Heterogeneous Porous Media?
TL;DR: Results from this research indicate that roughness primarily controlled the retention of MWCNTs, although goethite surfaces played an important secondary role.
Journal Article
Nanomaterial health effects--Part 2: Uncertainties and recommendations for the future
Maria Powell,Marty S. Kanarek +1 more
TL;DR: Some of the key data gaps, uncertainties, and unknowns that need to be addressed to develop adequate risk assessments for nanomaterials are summarized.
Journal ArticleDOI
Unzipping and binding of small interfering RNA with single walled carbon nanotube: A platform for small interfering RNA delivery
TL;DR: In this article, the authors combine all atom classical and quantum simulations to study the binding of small interfering RNA (siRNA) by pristine single wall carbon nanotube (SWCNT).
References
More filters
Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
Related Papers (5)
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Anna A. Shvedova,Elena R. Kisin,Robert R. Mercer,Ashley R. Murray,Victor J. Johnson,Alla I. Potapovich,Yulia Y. Tyurina,Olga Gorelik,Sevaram Arepalli,Diane Schwegler-Berry,Ann F. Hubbs,James M. Antonini,Douglas E. Evans,Bon Ki Ku,Dawn Ramsey,Andrew D. Maynard,Valerian E. Kagan,Vincent Castranova,Vincent Castranova,Paul A. Baron +19 more