Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Journal ArticleDOI
A Review on the Respiratory System Toxicity of Carbon Nanoparticles.
TL;DR: This article is intended to emphasize the potentially dangerous effects to the human respiratory system if inadequate measures are used in the manufacture, handling, and preparation and applications of CNP or CNP-based products.
Journal ArticleDOI
The effects of carbon nanotubes on lung and dermal cellular behaviors
TL;DR: The acute and chronic effects of CNT exposure on lung and dermal cellular behaviors are examined and the linkage of cellular behaviors and disease pathogenesis is examined, and the pertinent mechanisms are discussed.
Journal ArticleDOI
Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus
Ashish Jachak,Samuel K. Lai,Kaoru Hida,Jung Soo Suk,Nina Markovic,Shyam Biswal,Patrick N. Breysse,Justin Hanes +7 more
TL;DR: It is concluded that human mucus layers probably provide considerable protection for mucosal tissues from the penetration of most nMeOs and SWCNTs, and that further investigation of the potential health risks of exposure to ZnO nanoparticles is warranted.
Journal ArticleDOI
Proactively designing nanomaterials to enhance performance and minimise hazard
TL;DR: The approach to the development of benign nanoparticles begins with the synthesis of precisely engineered, high-purity nanoparticle libraries using the principles of green chemistry and utilises information gained from the biological studies to inform the nanomaterial design process until benign products and processes are identified.
Journal ArticleDOI
Effect of different carbon nanotubes on cell viability and proliferation
Milena De Nicola,Daniele Mirabile Gattia,Stefano Bellucci,Giovanni De Bellis,Federico Micciulla,Roberto Pastore,Alessandra Tiberia,Claudia Cerella,Maria D'alessio,Marco Vittori Antisari,Renzo Marazzi,Enrico Traversa,Andrea Magrini,Antonio Bergamaschi,Lina Ghibelli +14 more
TL;DR: Results show that CNTs, though not directly exerting a direct cytotoxic effect, are nonetheless able to deeply alter cell behaviour, and thus recommend thorough analyses to limit health risk due to uncontrolled exposure.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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