Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Journal ArticleDOI
Carboxylation of multiwalled carbon nanotube enhanced its biocompatibility with L02 cells through decreased activation of mitochondrial apoptotic pathway
Zhenbao Liu,Xia Dong,Liping Song,Hailing Zhang,Lanxia Liu,Dunwan Zhu,Cunxian Song,Xigang Leng +7 more
TL;DR: The data accumulated in this study revealed that modification with carboxyl group reduced the toxicity of MWCNT on L02 cells, probably due to the decreased activation of mitochondria mediated apoptotic pathway, suggesting thatCarboxylated MWC NT might be safer for in vivo application as compared with p-MWCNT.
Journal ArticleDOI
Banning carbon nanotubes would be scientifically unjustified and damaging to innovation
Daniel A. Heller,Daniel A. Heller,Prakrit V. Jena,Matteo Pasquali,Kostas Kostarelos,Lucia Gemma Delogu,Rachel E. Meidl,Slava V. Rotkin,David A. Scheinberg,David A. Scheinberg,Robert E. Schwartz,Mauricio Terrones,YuHuang Wang,Alberto Bianco,Ardemis A. Boghossian,Sofie Cambré,Laurent Cognet,Simon R. Corrie,Philip Demokritou,Silvia Giordani,Tobias Hertel,Tetyana Ignatova,Mohammad Islam,Nicole M. Iverson,Anand Jagota,Dawid Janas,Junichiro Kono,Sebastian Kruss,Markita P. Landry,Yan Li,Richard Martel,Shigeo Maruyama,Anton V. Naumov,Maurizio Prato,Maurizio Prato,Susan J. Quinn,Daniel Roxbury,Michael S. Strano,James M. Tour,R. Bruce Weisman,Wim Wenseleers,Masako Yudasaka +41 more
TL;DR: The inclusion of all carbon nanotubes in the SIN list discourages research and investment in these materials that are being applied, for instance, to treat kidney disease, track viral outbreaks and to investigate Parkinson’s disease.
Journal ArticleDOI
Quantum dot 705, a cadmium-based nanoparticle, induces persistent inflammation and granuloma formation in the mouse lung.
TL;DR: Assessment of the biological effects of QD705 in the lungs and the protective effects of polyethylene glycol (PEG) coating againstQD705-induced biological responses indicated that administration of Qd705 via the lung caused adverse responses and PEG coating failed to prevent these effects.
Journal ArticleDOI
Pulmonary Toxicity of 1‐D Nanocarbon Materials
Andrzej Huczko,Hubert Lange,Michał Bystrzejewski,P. Baranowski,Hanna Grubek-Jaworska,Patrycja Nejman,Tadeusz Przybyłowski,Katarzyna Czumińska,Jarosław Glapiński,D. R. M. Walton,Harold W. Kroto +10 more
TL;DR: In this article, the pulmonary toxicity of nanotubes was investigated and the results showed that both the duration of exposure and material characteristics can affect the respiratory process and induce pathological reaction in lung tissue.
Journal ArticleDOI
Current applications and future prospects of nanomaterials in tumor therapy.
TL;DR: This review summarizes the recent progress using the innate antitumor properties of metallic and nonmetallic nanomaterials to treat tumors, and related challenges and prospects are discussed.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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