Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Research strategies for safety evaluation of nanomaterials, Part I: evaluating the human health implications of exposure to nanoscale materials.
Karluss Thomas,Philip Sayre +1 more
TL;DR: The human health implications of exposure to nanoscales materials in the context of a toxicological risk evaluation are reviewed, the current scope of U.S. Federal research on nanoscale materials, and selected toxicological studies associated with nanoscALE materials are selected to note emerging research in this area are reviewed.
Journal ArticleDOI
Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2
Javed Ahmad,Maqusood Ahamed,Mohd Javed Akhtar,Salman A. H. Alrokayan,Maqsood A. Siddiqui,Javed Musarrat,Abdulaziz A. Al-Khedhairy +6 more
TL;DR: It is demonstrated that silica nanoparticles induced apoptosis in human liver cells, which is ROS mediated and regulated through p53, bax/bcl-2 and caspase pathways, and co-treatment of ROS scavenger vitamin C significantly attenuated the modulation of apoptotic markers along with the preservation of cell viability caused by silica Nanoparticles.
Journal ArticleDOI
The reliability and limits of the MTT reduction assay for carbon nanotubes-cell interaction
TL;DR: A careful validation of MTT assay procedures is suggested in experiments where CNTs are one of the constituents, to avoid a potential bias in concluding results of cytotoxicity studies.
Journal ArticleDOI
Genotoxicity of Silver Nanoparticles in Vicia faba: A Pilot Study on the Environmental Monitoring of Nanoparticles
TL;DR: It is demonstrated that AgNPs are genotoxic to plant cells, and plant assays have been integrated as a genotoxicity component in risk assessment for detection of environmental mutagens should be given full consideration when evaluating the overall toxicological impact of the nanoparticles in the environment.
Journal ArticleDOI
Factors influencing the partitioning and toxicity of nanotubes in the aquatic environment
Alan J. Kennedy,Matthew S. Hull,Jeffery A. Steevens,Katerina Dontsova,Mark A. Chappell,Jonas C. Gunter,Charles A. Weiss +6 more
TL;DR: It may be inappropriate to classify all NTs into one category in terms of their environmental regulation, and column stability and settling experiments indicated that raw, multiwalled NTs (MWNTs) settled more rapidly than carbon black and activated carbon particles, suggesting sediment as the ultimate repository.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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