Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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IL-1R signalling is critical for regulation of multi-walled carbon nanotubes-induced acute lung inflammation in C57Bl/6 mice
TL;DR: The results suggest that MWCNT were effective in inducing acute pulmonary inflammation and suggest that IL-1R signalling plays a crucial role in the regulation of M WCNT-induced pulmonary inflammation.
Journal ArticleDOI
Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells
Maricica Pacurari,Xue J. Yin,Min Ding,Steve Leonard,Diana Schwegler-berry,Barbara S. Ducatman,Madalina M. Chirila,Morinobu Endo,Vincent Castranova,Val Vallyathan +9 more
TL;DR: It is demonstrated that MWCNT are biologically potent activators of molecular events in NM cells associated with mesothelioma development and multiwall carbon nanotubes containing low iron content generated only negligible amounts of reactive oxygen species with both cells.
Journal ArticleDOI
Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats.
TL;DR: The results suggest the extra pulmonary toxicities of these carbon nanoparticles might be due to the translocation into the liver and kidney.
Journal ArticleDOI
Viability Studies of Pure Carbon‐ and Nitrogen‐Doped Nanotubes with Entamoeba histolytica: From Amoebicidal to Biocompatible Structures
Ana Laura Elías,Julio Cesar Carrero-Sánchez,Humberto Terrones,Morinobu Endo,Juan Pedro Laclette,Mauricio Terrones +5 more
Book
Nanomaterials for medical diagnosis and therapy
TL;DR: This work states that nanotechnologies for Diagnosis - Present and Future, as well as strategies for Targeted Delivery - Designed by Man, need to be reviewed for applicability in clinical practice.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Anna A. Shvedova,Elena R. Kisin,Robert R. Mercer,Ashley R. Murray,Victor J. Johnson,Alla I. Potapovich,Yulia Y. Tyurina,Olga Gorelik,Sevaram Arepalli,Diane Schwegler-Berry,Ann F. Hubbs,James M. Antonini,Douglas E. Evans,Bon Ki Ku,Dawn Ramsey,Andrew D. Maynard,Valerian E. Kagan,Vincent Castranova,Vincent Castranova,Paul A. Baron +19 more