Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
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Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo.
TL;DR: A future is envisioned, where carbon-based nano-containers, which are specifically designed to target organs/cells, deliver their cargo, and biodegrade via peroxidase-driven mechanism, will represent an attractive therapeutic delivery option in nanomedicine.
Journal ArticleDOI
Interfacing carbon nanotubes with living mammalian cells and cytotoxicity issues.
TL;DR: This work reviews the important studies pertaining to the internalization of CNTs into the cells and the culturing of cells on the CNT-based scaffold or support materials and focuses on a variety of factors affecting CNT cytotoxicity.
Journal ArticleDOI
Genotoxicity and ecotoxicity assays using the freshwater crustacean Daphnia magna and the larva of the aquatic midge Chironomus riparius to screen the ecological risks of nanoparticle exposure.
TL;DR: CeO(2) nanoparticles may be genotoxic toward aquatic organisms, which may contribute to the knowledge relating to the aquatic toxicity of the most widely used nanomaterials on aquatic ecosystems, for which little data is available.
Journal ArticleDOI
Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells.
Xiang Wang,Tian Xia,Susana Addo Ntim,Zhaoxia Ji,Saji George,Huan Meng,Haiyuan Zhang,Vincent Castranova,Somenath Mitra,Andre E. Nel +9 more
TL;DR: It is found that hydrophobicity is the major factor determining AP- and PD-MWCNT agglomeration in tissue culture media but that the ionic strength is the main factor determining COOH- MWCNT suspendability.
Journal ArticleDOI
Smaller is not always better: nanotechnology yields nanotoxicology.
Howard M. Kipen,Debra L. Laskin +1 more
TL;DR: The paper by Shvedova et al., the current article in focus (Ref. [15][1], see p. L698 in this issue), suggests some less-attractive perspectives of this vision of small is beautiful.
References
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Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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Anna A. Shvedova,Elena R. Kisin,Robert R. Mercer,Ashley R. Murray,Victor J. Johnson,Alla I. Potapovich,Yulia Y. Tyurina,Olga Gorelik,Sevaram Arepalli,Diane Schwegler-Berry,Ann F. Hubbs,James M. Antonini,Douglas E. Evans,Bon Ki Ku,Dawn Ramsey,Andrew D. Maynard,Valerian E. Kagan,Vincent Castranova,Vincent Castranova,Paul A. Baron +19 more